PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22130631-1 2012 BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO). Water 206-211 superoxide dismutase 2 Homo sapiens 26-56 22580338-4 2012 Upon knockdown of SOD2 by RNA interference, UM1 cells displayed significantly reduced migration and invasion abilities; reduced activities of SOD2; lower intracellular H(2)O(2); decreased protein levels of Snail, MMP1, and pERK1/2; and increased protein levels of E-cadherin. Water 168-173 superoxide dismutase 2 Homo sapiens 18-22 26596112-3 2015 In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity--APOE, PPARG, HTR2A, characterizing antioxidant system state--SOD2 and detoxication--SULTA. Water 46-51 superoxide dismutase 2 Homo sapiens 234-238 22130631-1 2012 BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO). Water 206-211 superoxide dismutase 2 Homo sapiens 58-63 20930427-8 2010 A defect of mitochondrial NDUFV1 may reduce complex I, which produces most of the superoxide, which is then scavenged by the mitochondrial enzyme Mn-superoxide dismutase to produce H(2)O(2). Water 181-186 superoxide dismutase 2 Homo sapiens 146-169 21386137-3 2011 Manganese superoxide dismutase (MnSOD) is the primary mitochondrial ROS scavenging enzyme that converts superoxide to hydrogen peroxide, which is subsequently converted to water by catalase and other peroxidases. Water 172-177 superoxide dismutase 2 Homo sapiens 0-30 21386137-3 2011 Manganese superoxide dismutase (MnSOD) is the primary mitochondrial ROS scavenging enzyme that converts superoxide to hydrogen peroxide, which is subsequently converted to water by catalase and other peroxidases. Water 172-177 superoxide dismutase 2 Homo sapiens 32-37 21445095-10 2011 From these results, we conclude that complex I-derived O(2) (-), produced through reverse electron transport due to enhanced metabolism and a high activity of complex I, was dismutated into H(2)O(2) by MnSOD induced via NF-kappaB activation and that the dismutated mH(2)O(2) stimulated muscle differentiation as a signaling messenger. Water 190-195 superoxide dismutase 2 Homo sapiens 202-207 15018733-1 2004 Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water. Water 249-254 superoxide dismutase 2 Homo sapiens 66-96 19229592-7 2009 LA, which is a water- and lipid-soluble antioxidant, decreased the protein expression of MnSOD, though mRNA levels and activities remained unchanged. Water 15-20 superoxide dismutase 2 Homo sapiens 89-94 19074884-13 2008 In a low-selenium population, SOD2-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting prostate tumor cell proliferation and migration. Water 227-232 superoxide dismutase 2 Homo sapiens 30-34 18413745-6 2008 We found that decreasing MnSOD with small interfering RNA in MCF-7 cells resulted in (a) an associated increase in the hypoxic accumulation of HIF-1 alpha immunoreactive protein, (b) a significant increase in the levels of O(2)(*-) (P < 0.01), but (c) no significant change in the steady-state level of H(2)O(2). Water 306-311 superoxide dismutase 2 Homo sapiens 25-30 16785034-6 2006 Overexpression of human manganese superoxide dismutase in PAEC reduced O(2)*(-) levels and attenuated cytotoxicity resulting from treatment with H(2)O(2). Water 145-150 superoxide dismutase 2 Homo sapiens 24-54 18349501-3 2007 It is of particular importance to photosynthetic organisms in the chloroplast of which a cluster of Mn atoms at the catalytic centre function in the light-induced water oxidation by photosystem II, and also function as a cofactor for a variety of enzymes, such as Mn-SOD. Water 163-168 superoxide dismutase 2 Homo sapiens 264-270 16910777-4 2006 The rate of aminotriazole-inhibited catalase activity also was increased when SOD2 is overexpressed and reflects a 1.6-fold increase in the steady-state production of H(2)O(2). Water 167-172 superoxide dismutase 2 Homo sapiens 78-82 15683235-6 2005 On the basis of our computational results as well as previously published kinetic data, we propose that the product-inhibited form of MnSOD is best described as a side-on peroxo-Mn3+ adduct possessing an axial H2O ligand. Water 210-213 superoxide dismutase 2 Homo sapiens 134-139 15018733-1 2004 Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water. Water 249-254 superoxide dismutase 2 Homo sapiens 98-103 12080470-6 2002 Indeed, the enzymatic activity of MnSOD is to transform the toxic O(2)(*)(-) in H(2)O(2). Water 80-85 superoxide dismutase 2 Homo sapiens 34-39 10455106-1 1999 The reduction with excess H(2)O(2) of human Mn(III) superoxide dismutase (SOD) and the active-site mutant Y34F Mn(III)SOD was measured by scanning stopped-flow spectrophotometry and revealed the presence of an intermediate in the reduction of the manganese. Water 26-31 superoxide dismutase 2 Homo sapiens 74-77 11912930-5 2002 The active site of MnSOD is dominated by a hydrogen bond network comprising the manganese-bound aqueous ligand, the side chains of four residues (Gln-143, Tyr-34, His-30, and Tyr-166 from an adjacent subunit), as well as other water molecules. Water 227-232 superoxide dismutase 2 Homo sapiens 19-24 10852710-3 2000 Two new water molecules in Q143A MnSOD were situated in positions nearly identical with the Oepsilon1 and Nepsilon2 of the replaced Gln 143 side chain and maintained a hydrogen-bonded network connecting the manganese-bound solvent molecule to other residues in the active site. Water 8-13 superoxide dismutase 2 Homo sapiens 33-38 11929218-8 2002 The calculations support a very important role for the conserved second sphere Gln in MnSOD in specifically destabilizing coordinated H2O relative to coordinated OH-, and thus disfavouring the oxidized state of the metal ion. Water 134-137 superoxide dismutase 2 Homo sapiens 86-91 11063906-0 2000 Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2). Water 196-201 superoxide dismutase 2 Homo sapiens 49-54 3838941-6 1985 Human manganese superoxide dismutase was also found to dismute the superoxide radical to hydrogen peroxide and water. Water 111-116 superoxide dismutase 2 Homo sapiens 6-36 9886257-2 1999 MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen. Water 170-175 superoxide dismutase 2 Homo sapiens 0-5 9288180-1 1997 BACKGROUND: Antioxidant enzymes (AEs), which catalyze the conversion of reactive oxygen species (ROS) to water, include catalase (CAT), manganese-containing superoxide dismutase (MnSOD), and copper and zinc-containing superoxide dismutase (CuZnSOD). Water 105-110 superoxide dismutase 2 Homo sapiens 179-184 29282552-10 2018 The water pK a in Mn-SOD is higher than that in Fe-SOD by 3.5 pH units, which is similar to the shift measured experimentally. Water 4-9 superoxide dismutase 2 Homo sapiens 18-24 33009206-2 2021 Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water. Water 209-214 superoxide dismutase 2 Homo sapiens 70-100 33009206-2 2021 Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water. Water 209-214 superoxide dismutase 2 Homo sapiens 102-106 31506286-5 2019 Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase. Water 153-158 superoxide dismutase 2 Homo sapiens 0-22 31506286-5 2019 Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase. Water 153-158 superoxide dismutase 2 Homo sapiens 24-28 29282552-10 2018 The water pK a in Mn-SOD is higher than that in Fe-SOD by 3.5 pH units, which is similar to the shift measured experimentally. Water 4-9 superoxide dismutase 2 Homo sapiens 21-24 28587495-1 2017 Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1). Water 159-164 superoxide dismutase 2 Homo sapiens 0-30 28587495-1 2017 Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1). Water 159-164 superoxide dismutase 2 Homo sapiens 32-37