PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16596811-4 2005 For instance, the ABCG5/ABCG8 couple is crucial for hepatobiliary and intestinal cholesterol excretion, while ABCA1 is essential for high-density lipoprotein formation and, hence, for inter-organ trafficking of the highly water-insoluble cholesterol molecules. Water 222-227 ATP binding cassette subfamily G member 5 Homo sapiens 18-23 33228147-5 2020 We demonstrated a sterol-coupled ATPase activity of ABCG5/G8 by cholesteryl hemisuccinate (CHS), a relatively water-soluble cholesterol memetic, and characterized CHS-coupled ATPase activity of three loss-of-function missense variants, R543S, E146Q, and A540F, which are respectively within, in contact with, and distant from the polar relay. Water 110-115 ATP binding cassette subfamily G member 5 Homo sapiens 52-57