PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16940083-1 2006 Metabolic activation of pradefovir to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) was evaluated by using cDNA-expressed CYP isozymes in portal vein-cannulated rats following oral administration and in human liver microsomes. adefovir 38-73 peptidylprolyl isomerase G Homo sapiens 119-122 16940083-1 2006 Metabolic activation of pradefovir to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) was evaluated by using cDNA-expressed CYP isozymes in portal vein-cannulated rats following oral administration and in human liver microsomes. adefovir 75-79 peptidylprolyl isomerase G Homo sapiens 119-122 16940083-3 2006 The results indicated that CYP3A4 is the only cDNA-expressed CYP isozyme catalyzing the conversion of pradefovir to PMEA. adefovir 116-120 peptidylprolyl isomerase G Homo sapiens 27-30