PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17210706-5	2007	In the absence of alterations in plasma PMEA levels, Mrp4-null mice treated with PMEA exhibit increased lethality associated with marked toxicity in several tissues.	adefovir	81-85	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	53-57	
17110501-0	2007	Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.	adefovir	129-137	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	69-73	
17110501-0	2007	Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.	adefovir	129-137	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	74-79	
17110501-3	2007	ATP-dependent uptake of adefovir and tenofovir but not cidofovir was observed only in the membrane vesicles expressing MRP4.	adefovir	24-32	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	119-123	
17110501-4	2007	The ATP-dependent uptake of adefovir and tenofovir by MRP4 was not saturated at 1 mM.	adefovir	28-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	54-58	
17110501-5	2007	The ATP-dependent uptake of adefovir by membrane vesicles expressing MRP4 was osmotic-sensitive.	adefovir	28-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	69-73	
17110501-8	2007	The kidney accumulation of adefovir and tenofovir was significantly greater in Mrp4 knockout mice (130 versus 66 and 191 versus 87 pmol/g tissue, respectively); thus, the renal luminal efflux clearance was estimated to be 37 and 46%, respectively, of the control.	adefovir	27-35	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	79-83	
17110501-12	2007	Our results suggest that MRP4 is involved in the luminal efflux of both adefovir and tenofovir, but it makes only a limited contribution to the urinary excretion of cidofovir.	adefovir	72-80	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	25-29	
17210706-7	2007	In addition, PMEA penetration into the brain is increased in Mrp4(-/-) mice.	adefovir	13-17	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	61-65	
23775562-8	2013	In contrast, targeted inactivation of Abcc4/Mrp4 in mouse cells specifically enhanced nelfinavir and 9-(2-phosphonylmethoxyethyl) adenine cytotoxicity.	adefovir	101-137	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	38-43	
11106685-13	2000	CONCLUSIONS: These results indicate that MRP4 confers resistance to short-term methotrexate and continuous PMEA treatment.	adefovir	107-111	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	41-45	
23775562-8	2013	In contrast, targeted inactivation of Abcc4/Mrp4 in mouse cells specifically enhanced nelfinavir and 9-(2-phosphonylmethoxyethyl) adenine cytotoxicity.	adefovir	101-137	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	44-48