PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19735648-0 2010 Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil. adefovir 95-103 ATP binding cassette subfamily C member 4 Homo sapiens 39-43 19735648-10 2010 A comparison of these data with the reduction in the basolateral egress of adefovir by the general MRP inhibitor indomethacin established that MRP4, among MRPs, plays a predominant role in the basolateral egress of adefovir in Caco-2 cells. adefovir 75-83 ATP binding cassette subfamily C member 4 Homo sapiens 143-147 19735648-10 2010 A comparison of these data with the reduction in the basolateral egress of adefovir by the general MRP inhibitor indomethacin established that MRP4, among MRPs, plays a predominant role in the basolateral egress of adefovir in Caco-2 cells. adefovir 215-223 ATP binding cassette subfamily C member 4 Homo sapiens 143-147 11802779-7 2002 ABCC4 also mediates resistance to purine analogues 9-(2-phosphonylmethoxyethyl)-adenine and 6-thioguanine. adefovir 51-87 ATP binding cassette subfamily C member 4 Homo sapiens 0-5 16868766-8 2007 Similar to the case for other MRPs that possess only two membrane spanning domains (MRP4 and MRP5), MRP8 is a cyclic nucleotide efflux pump that is able to confer resistance to nucleoside-based agents, such as PMEA and 5FU. adefovir 210-214 ATP binding cassette subfamily C member 4 Homo sapiens 84-88 12695538-4 2003 In cytotoxicity assays, MRP4 conferred resistance to the antiviral agent 9-(2-phosphonomethoxyethyl)adenine (PMEA) and high-performance liquid chromatography analysis showed that, like MRP5, MRP4 transported PMEA in an unmodified form. adefovir 73-107 ATP binding cassette subfamily C member 4 Homo sapiens 24-28 12695538-4 2003 In cytotoxicity assays, MRP4 conferred resistance to the antiviral agent 9-(2-phosphonomethoxyethyl)adenine (PMEA) and high-performance liquid chromatography analysis showed that, like MRP5, MRP4 transported PMEA in an unmodified form. adefovir 73-107 ATP binding cassette subfamily C member 4 Homo sapiens 191-195 12695538-4 2003 In cytotoxicity assays, MRP4 conferred resistance to the antiviral agent 9-(2-phosphonomethoxyethyl)adenine (PMEA) and high-performance liquid chromatography analysis showed that, like MRP5, MRP4 transported PMEA in an unmodified form. adefovir 109-113 ATP binding cassette subfamily C member 4 Homo sapiens 24-28 12695538-4 2003 In cytotoxicity assays, MRP4 conferred resistance to the antiviral agent 9-(2-phosphonomethoxyethyl)adenine (PMEA) and high-performance liquid chromatography analysis showed that, like MRP5, MRP4 transported PMEA in an unmodified form. adefovir 208-212 ATP binding cassette subfamily C member 4 Homo sapiens 24-28 18559527-6 2008 Increased plasma membrane MRP4 was accompanied by increased efflux function as reflected by reduced cellular accumulation of the MRP4 substrates 6-mercaptopurine and 9-[2-(phosphonylmethoxy)ethyl]-adenine. adefovir 166-204 ATP binding cassette subfamily C member 4 Homo sapiens 26-30 18364470-6 2008 The function of MRP4 variants was compared by measuring the intracellular accumulation of two antiviral agents, azidothymidine (AZT) and adefovir (PMEA). adefovir 137-145 ATP binding cassette subfamily C member 4 Homo sapiens 16-20 18364470-6 2008 The function of MRP4 variants was compared by measuring the intracellular accumulation of two antiviral agents, azidothymidine (AZT) and adefovir (PMEA). adefovir 147-151 ATP binding cassette subfamily C member 4 Homo sapiens 16-20 18364470-10 2008 However, two variants (G187W and G487E) showed a significantly reduced function compared to reference with both substrates, as evidenced by higher intracellular accumulation of AZT and PMEA compared to the reference MRP4 (43 and 69% increase in accumulation for G187W compared with the reference MRP4, with AZT and PMEA, respectively). adefovir 185-189 ATP binding cassette subfamily C member 4 Homo sapiens 216-220 18364470-10 2008 However, two variants (G187W and G487E) showed a significantly reduced function compared to reference with both substrates, as evidenced by higher intracellular accumulation of AZT and PMEA compared to the reference MRP4 (43 and 69% increase in accumulation for G187W compared with the reference MRP4, with AZT and PMEA, respectively). adefovir 185-189 ATP binding cassette subfamily C member 4 Homo sapiens 296-300 18364470-10 2008 However, two variants (G187W and G487E) showed a significantly reduced function compared to reference with both substrates, as evidenced by higher intracellular accumulation of AZT and PMEA compared to the reference MRP4 (43 and 69% increase in accumulation for G187W compared with the reference MRP4, with AZT and PMEA, respectively). adefovir 315-319 ATP binding cassette subfamily C member 4 Homo sapiens 296-300 11447229-2 2001 Human multidrug resistance protein 4 (MRP4) has recently been determined to confer resistance to the antiviral purine analog 9-(2-phosphonylmethoxyethyl)adenine and methotrexate. adefovir 125-160 ATP binding cassette subfamily C member 4 Homo sapiens 6-36 11804191-5 2001 MRP4 and MRP5 resemble each other more closely than they resemble MRPs 1-3 and confer resistance to purine and nucleotide analogs which are either inherently anionic, as in the case of the anti-AIDS drug PMEA, or are phosphorylated and converted to anionic amphiphiles in the cell, as in the case of 6-MP. adefovir 204-208 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 12423063-4 2002 We first identified, MRP4, based on its ability to efflux antiretroviral compounds, such as azidothymidine monophosphate (AZT-MP) and 9-(2-phosphonyl methoxyethyl) adenine (PMEA), in drug-resistant and also in transfected cell lines. adefovir 134-171 ATP binding cassette subfamily C member 4 Homo sapiens 21-25 12423063-4 2002 We first identified, MRP4, based on its ability to efflux antiretroviral compounds, such as azidothymidine monophosphate (AZT-MP) and 9-(2-phosphonyl methoxyethyl) adenine (PMEA), in drug-resistant and also in transfected cell lines. adefovir 173-177 ATP binding cassette subfamily C member 4 Homo sapiens 21-25 11447229-2 2001 Human multidrug resistance protein 4 (MRP4) has recently been determined to confer resistance to the antiviral purine analog 9-(2-phosphonylmethoxyethyl)adenine and methotrexate. adefovir 125-160 ATP binding cassette subfamily C member 4 Homo sapiens 38-42 25674464-4 2014 At 4-hr exposure HEK/MRP4 cells were 2-4-fold resistant to troxacitabine, ara-C and 9-(2-phosphonylmethoxyethyl)adenine (PMEA), and HEK/MRP5i to ara-C and PMEA, but none to GEM. adefovir 84-119 ATP binding cassette subfamily C member 4 Homo sapiens 21-25 30372692-13 2018 Expression of MRP4, a nucleoside transporter, appeared to influence the response of AML cells to ODE-adefovir, as its inhibition potentiated ODE-adefovir killing. adefovir 101-109 ATP binding cassette subfamily C member 4 Homo sapiens 14-18 10944550-7 2000 MRP4 overexpression is associated with high-level resistance to the nucleoside analogues 9-(2-phosphonylmethoxyethyl) adenine and azidothymidine, both of which are used as anti-human immunodeficiency virus drugs. adefovir 89-125 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 10470083-6 1999 In our study of alternative or additional mechanisms of resistance operating during antiviral therapy, overexpression and amplification of the MRP4 gene correlated with ATP-dependent efflux of PMEA (9-(2-phosphonylmethoxyethyl)adenine) and azidothymidine monophosphate from cells and, thus, with resistance to these drugs. adefovir 193-197 ATP binding cassette subfamily C member 4 Homo sapiens 143-147 10470083-6 1999 In our study of alternative or additional mechanisms of resistance operating during antiviral therapy, overexpression and amplification of the MRP4 gene correlated with ATP-dependent efflux of PMEA (9-(2-phosphonylmethoxyethyl)adenine) and azidothymidine monophosphate from cells and, thus, with resistance to these drugs. adefovir 199-234 ATP binding cassette subfamily C member 4 Homo sapiens 143-147 10470083-7 1999 Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs. adefovir 89-93 ATP binding cassette subfamily C member 4 Homo sapiens 18-22 10470083-7 1999 Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs. adefovir 89-93 ATP binding cassette subfamily C member 4 Homo sapiens 32-36 10470083-8 1999 Increased resistance to PMEA and amplification of the MRP4 gene correlated with enhanced drug efflux; transfer of chromosome 13 containing the amplified MRP4 gene conferred resistance to PMEA. adefovir 187-191 ATP binding cassette subfamily C member 4 Homo sapiens 153-157 28960749-3 2018 Efflux of [3 H]-9-(2-phosphonomethoxyethyl) adenine ([3 H]-PMEA), a known ABCC4 substrate in humans, was detected from PhABCC4 cRNA-injected oocytes by liquid scintillation spectrophotometric analysis and PhABCC4 expression in oocytes was confirmed using ABC transporter inhibitors. adefovir 59-63 ATP binding cassette subfamily C member 4 Homo sapiens 74-79 25674464-4 2014 At 4-hr exposure HEK/MRP4 cells were 2-4-fold resistant to troxacitabine, ara-C and 9-(2-phosphonylmethoxyethyl)adenine (PMEA), and HEK/MRP5i to ara-C and PMEA, but none to GEM. adefovir 121-125 ATP binding cassette subfamily C member 4 Homo sapiens 21-25 25674464-4 2014 At 4-hr exposure HEK/MRP4 cells were 2-4-fold resistant to troxacitabine, ara-C and 9-(2-phosphonylmethoxyethyl)adenine (PMEA), and HEK/MRP5i to ara-C and PMEA, but none to GEM. adefovir 155-159 ATP binding cassette subfamily C member 4 Homo sapiens 21-25 24436471-6 2014 When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4. adefovir 178-186 ATP binding cassette subfamily C member 4 Homo sapiens 72-76 24436471-6 2014 When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4. adefovir 178-186 ATP binding cassette subfamily C member 4 Homo sapiens 121-125 24436471-6 2014 When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4. adefovir 178-186 ATP binding cassette subfamily C member 4 Homo sapiens 121-125 24436471-6 2014 When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4. adefovir 178-186 ATP binding cassette subfamily C member 4 Homo sapiens 121-125 23775562-10 2013 Because nelfinavir is a new MRP4/ABCC4 substrate, we developed a MRP4/ABCC4 pharmacophore model, which showed that the nelfinavir binding site is shared with chemotherapeutic substrates such as adefovir and methotrexate. adefovir 194-202 ATP binding cassette subfamily C member 4 Homo sapiens 28-32 23775562-10 2013 Because nelfinavir is a new MRP4/ABCC4 substrate, we developed a MRP4/ABCC4 pharmacophore model, which showed that the nelfinavir binding site is shared with chemotherapeutic substrates such as adefovir and methotrexate. adefovir 194-202 ATP binding cassette subfamily C member 4 Homo sapiens 33-38 23775562-10 2013 Because nelfinavir is a new MRP4/ABCC4 substrate, we developed a MRP4/ABCC4 pharmacophore model, which showed that the nelfinavir binding site is shared with chemotherapeutic substrates such as adefovir and methotrexate. adefovir 194-202 ATP binding cassette subfamily C member 4 Homo sapiens 65-69 23775562-10 2013 Because nelfinavir is a new MRP4/ABCC4 substrate, we developed a MRP4/ABCC4 pharmacophore model, which showed that the nelfinavir binding site is shared with chemotherapeutic substrates such as adefovir and methotrexate. adefovir 194-202 ATP binding cassette subfamily C member 4 Homo sapiens 70-75