PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31581474-2	2019	Interestingly, when an FDA-approved drug library was tested for agents that block peroxisome proliferator-activated receptor gamma (PPARgamma) phosphorylation at Ser245 to evaluate possibilities of antidiabetic drug repositioning, imatinib was determined as a PPARgamma antagonist ligand.	imatinib	231-239	peroxisome proliferator activated receptor gamma	Homo sapiens	82-130	
31648125-1	2020	Recent studies examined the possibility to overcome imatinib resistance in chronic myeloid leukemia (CML) patients by combination therapy with peroxisome proliferator-activated receptor gamma (PPARgamma) ligands.	imatinib	52-60	peroxisome proliferator activated receptor gamma	Homo sapiens	143-191	
31648125-1	2020	Recent studies examined the possibility to overcome imatinib resistance in chronic myeloid leukemia (CML) patients by combination therapy with peroxisome proliferator-activated receptor gamma (PPARgamma) ligands.	imatinib	52-60	peroxisome proliferator activated receptor gamma	Homo sapiens	193-202	
31581474-0	2019	Structural Basis for the Regulation of PPARgamma Activity by Imatinib.	imatinib	61-69	peroxisome proliferator activated receptor gamma	Homo sapiens	39-48	
31581474-3	2019	However, it is not well understood how imatinib binds to PPARgamma or would improve insulin sensitivity without classical agonism.	imatinib	39-47	peroxisome proliferator activated receptor gamma	Homo sapiens	57-66	
31581474-4	2019	Here, we report the crystal structure of the PPARgamma R288A mutant in complex with imatinib.	imatinib	84-92	peroxisome proliferator activated receptor gamma	Homo sapiens	45-54	
31581474-5	2019	Imatinib bound to Arm2 and Arm3 regions in the ligand-binding domain (LBD) of PPARgamma, of which the Arm3 region is closely related to the inhibition of PPARgamma phosphorylation at Ser245.	imatinib	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	78-87	
31581474-5	2019	Imatinib bound to Arm2 and Arm3 regions in the ligand-binding domain (LBD) of PPARgamma, of which the Arm3 region is closely related to the inhibition of PPARgamma phosphorylation at Ser245.	imatinib	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	154-163	
31581474-8	2019	Our study provides new structural insights into the PPARgamma regulation by imatinib and may contribute to the development of new antidiabetic drugs targeting PPARgamma while minimizing known side effects.	imatinib	76-84	peroxisome proliferator activated receptor gamma	Homo sapiens	52-61	
31581474-8	2019	Our study provides new structural insights into the PPARgamma regulation by imatinib and may contribute to the development of new antidiabetic drugs targeting PPARgamma while minimizing known side effects.	imatinib	76-84	peroxisome proliferator activated receptor gamma	Homo sapiens	159-168