PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31427972-0 2019 Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappaB Signaling. Scopoletin 0-10 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 128-137 31427972-2 2019 In the present study, we showed that Scopoletin effectively ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through novel regulatory mechanisms involving inhibition of NF-kappaB activity in dendritic cells (DCs). Scopoletin 37-47 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 225-234 31427972-5 2019 Consistent with the in vivo data, Scopoletin-treated, bone marrow-derived dendritic cells (BM-DCs) exhibited reduced expression of MHC class II and costimulatory molecules (e.g., CD80 and CD86) and reduced NF-kappaB phosphorylation. Scopoletin 34-44 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 206-215 28921708-5 2017 Scopoletin or metformin down-regulated hepatic gene expression of triglyceride (Pparg, Plpp2, and Dgat2) and cholesterol (Hmgcr) synthesis as well as inflammation (Tlr4, Myd88, Nfkb1, Tnfa, and Il6), while it up-regulated Cyp7a1 gene. Scopoletin 0-10 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 177-182