PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8927049-6 1995 Furthermore, treatment of CSV3-1 cells with genistein abolishes the effects of vanadate on protein tyrosine phosphorylation and c-jun induction. Vanadates 79-87 jun proto-oncogene Mus musculus 128-133 9062890-0 1997 Induction of AP-1 activity associated with c-Jun and JunB is required for mitogenesis induced by insulin and vanadate in SV40-transformed 3T3T cells. Vanadates 109-117 jun proto-oncogene Mus musculus 13-17 9062890-0 1997 Induction of AP-1 activity associated with c-Jun and JunB is required for mitogenesis induced by insulin and vanadate in SV40-transformed 3T3T cells. Vanadates 109-117 jun proto-oncogene Mus musculus 43-48 9062890-2 1997 Mitogenesis induced by insulin and vanadate in CSV3-1 cells is associated with the induction of the expression of protooncogenes c-jun and junB, two major AP-1 transcription factor components. Vanadates 35-43 jun proto-oncogene Mus musculus 129-134 9062890-2 1997 Mitogenesis induced by insulin and vanadate in CSV3-1 cells is associated with the induction of the expression of protooncogenes c-jun and junB, two major AP-1 transcription factor components. Vanadates 35-43 jun proto-oncogene Mus musculus 155-159 9062890-3 1997 We now report that both insulin and vanadate induce a significant increase in AP-1 DNA binding activity in CSV3-1 cells but not in 3T3T cells. Vanadates 36-44 jun proto-oncogene Mus musculus 78-82 9062890-4 1997 Gel supershift assays and Western blot analysis using specific antibodies demonstrate that the increased AP-1 binding activity induced by insulin and vanadate in CSV3-1 cells is primarily contributed by an increase in the expression of c-Jun and JunB protein levels. Vanadates 150-158 jun proto-oncogene Mus musculus 105-109 9062890-4 1997 Gel supershift assays and Western blot analysis using specific antibodies demonstrate that the increased AP-1 binding activity induced by insulin and vanadate in CSV3-1 cells is primarily contributed by an increase in the expression of c-Jun and JunB protein levels. Vanadates 150-158 jun proto-oncogene Mus musculus 236-241 9062890-5 1997 Furthermore, treatment of CSV3-1 cells with antisense oligodeoxyribonucleotides to c-jun or to junB blocks insulin- and vanadate-induced mitogenesis whereas antisense junD oligomers have no inhibitory effects. Vanadates 120-128 jun proto-oncogene Mus musculus 83-88 9062890-7 1997 Additional data presented in this paper show that JunD/AP-1 binding activity, which is thought to play a negative role in regulating cell proliferation, is also slightly induced following insulin and vanadate stimulation in CSV3-1 cells. Vanadates 200-208 jun proto-oncogene Mus musculus 55-59 9062890-8 1997 Nevertheless, the ratio of proliferation promoting c-Jun/AP-1 and JunB/AP-1 binding activities to proliferation inhibiting JunD/AP-1 binding activity is significantly increased following insulin and vanadate stimulation. Vanadates 199-207 jun proto-oncogene Mus musculus 51-56 9062890-8 1997 Nevertheless, the ratio of proliferation promoting c-Jun/AP-1 and JunB/AP-1 binding activities to proliferation inhibiting JunD/AP-1 binding activity is significantly increased following insulin and vanadate stimulation. Vanadates 199-207 jun proto-oncogene Mus musculus 57-61 9062890-8 1997 Nevertheless, the ratio of proliferation promoting c-Jun/AP-1 and JunB/AP-1 binding activities to proliferation inhibiting JunD/AP-1 binding activity is significantly increased following insulin and vanadate stimulation. Vanadates 199-207 jun proto-oncogene Mus musculus 71-75 9062890-8 1997 Nevertheless, the ratio of proliferation promoting c-Jun/AP-1 and JunB/AP-1 binding activities to proliferation inhibiting JunD/AP-1 binding activity is significantly increased following insulin and vanadate stimulation. Vanadates 199-207 jun proto-oncogene Mus musculus 71-75 23643895-8 2013 Specific inhibition of p-Akt by wortmannin did not affect cholesterol"s stimulation of the expression of c-Jun and Jun-B, however the vanadate effect of increasing p-ERK1/2, inhibited c-Jun expression, specifically, and the MBCD effect of increasing p-ERK and inhibiting p-Akt reduced c-Jun expression. Vanadates 134-142 jun proto-oncogene Mus musculus 184-189 23643895-8 2013 Specific inhibition of p-Akt by wortmannin did not affect cholesterol"s stimulation of the expression of c-Jun and Jun-B, however the vanadate effect of increasing p-ERK1/2, inhibited c-Jun expression, specifically, and the MBCD effect of increasing p-ERK and inhibiting p-Akt reduced c-Jun expression. Vanadates 134-142 jun proto-oncogene Mus musculus 184-189 1435769-5 1992 Expression of a third gene affected by vanadium, c-jun, was augmented by addition of a reductant or oxidant together with the vanadate. Vanadates 126-134 jun proto-oncogene Mus musculus 49-54 7524489-3 1994 UV-irradiated unsensitized cells did not reveal DNA fragmentation but showed increased expression of c-jun and greater protein tyrosine phosphorylation in response to sodium vanadate, an inhibitor of tyrosine phosphatases. Vanadates 167-182 jun proto-oncogene Mus musculus 101-106 1330658-2 1992 In these quiescent cells, insulin- and vanadate-induced mitogenesis are both associated with the induction of the c-jun proto-oncogene (Wang and Scott 1991 J. Vanadates 39-47 jun proto-oncogene Mus musculus 114-119 1330658-8 1992 The current studies were therefore designed to compare the early signal transduction pathways employed by insulin and vanadate to regulate c-jun expression. Vanadates 118-126 jun proto-oncogene Mus musculus 139-144 1330658-12 1992 In contrast, vanadate induction of c-jun is not affected by pertussis toxin. Vanadates 13-21 jun proto-oncogene Mus musculus 35-40 1330658-13 1992 Genistein, a general tyrosine kinase inhibitor, can inhibit the ability of vanadate to induce c-jun but it does not inhibit insulin"s effect. Vanadates 75-83 jun proto-oncogene Mus musculus 94-99 1330658-15 1992 These observations indicate that the c-jun induction by insulin and vanadate in CSV3-1 cells is mediated by different signal transduction mechanisms. Vanadates 68-76 jun proto-oncogene Mus musculus 37-42 1435769-6 1992 Addition of NADH (marginally effective on its own) or H2O2 (effective alone) dramatically enhanced the effect of vanadate on c-jun gene expression. Vanadates 113-121 jun proto-oncogene Mus musculus 125-130 1667087-9 1991 In contrast, vanadate induced the expression of c-jun, jun-B, and ornithine decarboxylase without inducing c-fos and c-myc. Vanadates 13-21 jun proto-oncogene Mus musculus 48-53