PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10585421-5 1999 The inhibitory effect of PE on IL-6 activation of STAT3 was also abolished by the tyrosine phosphatase inhibitor sodium vanadate, indicating involvement of protein tyrosine phosphatases. Vanadates 113-128 interleukin 6 Homo sapiens 31-35 10862623-1 2000 Modulation of HSF by vanadate and wortmannin. Vanadates 21-29 interleukin 6 Homo sapiens 14-17 9808582-11 1998 Third, the use of vanadate, a potent inhibitor of protein tyrosine phosphatase (PTP), abrogated the IL-6-induced proliferation in the CD45(+) myeloma cells. Vanadates 18-26 interleukin 6 Homo sapiens 100-104 12101275-7 2002 Inhibition was specific for IL-6, as induction of STAT activation by IFN-gamma, IFN-alpha, and vanadate was not inhibited. Vanadates 95-103 interleukin 6 Homo sapiens 28-32 15591791-0 2004 Vanadate stimulates monocytic differentiation activity of IL-6 by enhancing actin filament polymerization in HL-60 cells. Vanadates 0-8 interleukin 6 Homo sapiens 58-62 15591791-4 2004 In the presence of vanadate (10 microM), a PTP inhibitor, IL-6 induced pronounced G0/G1 cell cycle arrest; this effect was associated with CD14+ monocytic differentiation as well as F-actin filament polymerization. Vanadates 19-27 interleukin 6 Homo sapiens 58-62 15591791-5 2004 Furthermore, vanadate potentiated IL-6-signaling pathway by increasing the tyrosine phosphorylated levels of STAT3 (Tyr705), and Lyn. Vanadates 13-21 interleukin 6 Homo sapiens 34-38 15591791-7 2004 Vanadate also cooperated with IL-6 to form a protein complex containing Lyn and an actin-associated protein, AFAP110. Vanadates 0-8 interleukin 6 Homo sapiens 30-34 15591791-9 2004 In conclusion, inhibition of PTP by vanadate promotes hematopoietic differentiation activity of IL-6 through modulating multiple signalings, particularly actin filament polymerization. Vanadates 36-44 interleukin 6 Homo sapiens 96-100 14979481-4 2004 IL-6-induced proliferation in CD45+ U266 cells was inhibited by vanadate, a potent protein tyrosine phosphatase inhibitor. Vanadates 64-72 interleukin 6 Homo sapiens 0-4