PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9484843-9	1998	Inhibition of tyrosine phosphatases by orthovanadate pretreatment prolongs the time of JNK induction in response to both platinum compounds.	Vanadates	39-52	mitogen-activated protein kinase 8	Homo sapiens	87-90	
15308849-9	2004	When the cells were pretreated with vanadate or Ro318220, TNF-alpha-induced JNK activation was greatly prolonged, which was associated with the induction of cell death.	Vanadates	36-44	mitogen-activated protein kinase 8	Homo sapiens	76-79	
12454017-0	2003	Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro.	Vanadates	21-29	mitogen-activated protein kinase 8	Homo sapiens	14-17	
11466617-7	2001	Pretreatment of control cells with the phosphatase inhibitor vanadate greatly prolonged JNK activation by TNF alpha and resulted in induction of apoptosis by this cytokine.	Vanadates	61-69	mitogen-activated protein kinase 8	Homo sapiens	88-91	
10400652-2	1999	Treatment of macrophages with vanadate results in the activation of both NF-kappaB and c-Jun N-terminal kinase (JNK).	Vanadates	30-38	mitogen-activated protein kinase 8	Homo sapiens	87-110	
10400652-2	1999	Treatment of macrophages with vanadate results in the activation of both NF-kappaB and c-Jun N-terminal kinase (JNK).	Vanadates	30-38	mitogen-activated protein kinase 8	Homo sapiens	112-115	
10085098-8	1999	Hence, treatment of Bcl-xL cells with sodium vanadate, a tyrosine phosphatase inhibitor, restores MMS-induced activation of RAFTK and JNK.	Vanadates	38-53	mitogen-activated protein kinase 8	Homo sapiens	134-137	
12454017-7	2003	Vanadate-induced FasL expression was ROS-dependent but JNK-independent.	Vanadates	0-8	mitogen-activated protein kinase 8	Homo sapiens	55-58	
12454017-8	2003	In contrast, vanadate-elicited Fas aggregation and Fas-FADD association, as well as caspase-8 activation, were dependent on JNK activation but were minimally regulated by ROS generation.	Vanadates	13-21	mitogen-activated protein kinase 8	Homo sapiens	124-127	
12454017-11	2003	Thus, JNK signaling plays a major role in vanadate-mediated activation of the Fas-FADD-caspase-8 pathway that accounts for vanadate-induced apoptosis of CGPs.	Vanadates	42-50	mitogen-activated protein kinase 8	Homo sapiens	6-9	
12454017-11	2003	Thus, JNK signaling plays a major role in vanadate-mediated activation of the Fas-FADD-caspase-8 pathway that accounts for vanadate-induced apoptosis of CGPs.	Vanadates	123-131	mitogen-activated protein kinase 8	Homo sapiens	6-9	
12186877-8	2002	Inhibition of MKP-1 by vanadate enhanced JNK phosphorylation and attenuated the antiapoptotic effect of t-RA.	Vanadates	23-31	mitogen-activated protein kinase 8	Homo sapiens	41-44	
10595652-3	1999	Vanadate induced activation of three families of MAPKs, extracellular signal-regulated kinases 1 and 2 (ERK1/2), p38, and c-Jun amino-terminal kinase (JNK) 1, while activation of ERK 1/2 alone was induced by PMA.	Vanadates	0-8	mitogen-activated protein kinase 8	Homo sapiens	122-157	
10400652-6	1999	Conversely, blockage of JNK activation by transfection of a kinase-inactive form of SEK1 resulted in partially inhibition of vanadate-induced IkappaBalpha degradation.	Vanadates	125-133	mitogen-activated protein kinase 8	Homo sapiens	24-27	
10400652-7	1999	Both vanadate-induced degradation of IkappaBalpha and activation of JNK were potently inhibited by pretreatment of cells with N-acetylcysteine or dimercaprol.	Vanadates	5-13	mitogen-activated protein kinase 8	Homo sapiens	68-71	
10400652-8	1999	These results demonstrate that early activation of stress kinases or change of cellular redox states plays a key role in vanadate-induced activation of NF-kappaB and JNK.	Vanadates	121-129	mitogen-activated protein kinase 8	Homo sapiens	166-169	
10343170-6	1999	In this study we confirm these results and show that the protein tyrosine phosphatase inhibitor sodium vanadate activates ERK, JNK and Akt/PKB, but does not stimulate proliferation.	Vanadates	96-111	mitogen-activated protein kinase 8	Homo sapiens	127-130