PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12454017-0 2003 Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro. Vanadates 21-29 mitogen-activated protein kinase 8 Homo sapiens 14-17 15308849-9 2004 When the cells were pretreated with vanadate or Ro318220, TNF-alpha-induced JNK activation was greatly prolonged, which was associated with the induction of cell death. Vanadates 36-44 mitogen-activated protein kinase 8 Homo sapiens 76-79 12454017-7 2003 Vanadate-induced FasL expression was ROS-dependent but JNK-independent. Vanadates 0-8 mitogen-activated protein kinase 8 Homo sapiens 55-58 12454017-8 2003 In contrast, vanadate-elicited Fas aggregation and Fas-FADD association, as well as caspase-8 activation, were dependent on JNK activation but were minimally regulated by ROS generation. Vanadates 13-21 mitogen-activated protein kinase 8 Homo sapiens 124-127 12454017-11 2003 Thus, JNK signaling plays a major role in vanadate-mediated activation of the Fas-FADD-caspase-8 pathway that accounts for vanadate-induced apoptosis of CGPs. Vanadates 42-50 mitogen-activated protein kinase 8 Homo sapiens 6-9 12454017-11 2003 Thus, JNK signaling plays a major role in vanadate-mediated activation of the Fas-FADD-caspase-8 pathway that accounts for vanadate-induced apoptosis of CGPs. Vanadates 123-131 mitogen-activated protein kinase 8 Homo sapiens 6-9 12186877-8 2002 Inhibition of MKP-1 by vanadate enhanced JNK phosphorylation and attenuated the antiapoptotic effect of t-RA. Vanadates 23-31 mitogen-activated protein kinase 8 Homo sapiens 41-44 11466617-7 2001 Pretreatment of control cells with the phosphatase inhibitor vanadate greatly prolonged JNK activation by TNF alpha and resulted in induction of apoptosis by this cytokine. Vanadates 61-69 mitogen-activated protein kinase 8 Homo sapiens 88-91 9484843-9 1998 Inhibition of tyrosine phosphatases by orthovanadate pretreatment prolongs the time of JNK induction in response to both platinum compounds. Vanadates 39-52 mitogen-activated protein kinase 8 Homo sapiens 87-90 10595652-3 1999 Vanadate induced activation of three families of MAPKs, extracellular signal-regulated kinases 1 and 2 (ERK1/2), p38, and c-Jun amino-terminal kinase (JNK) 1, while activation of ERK 1/2 alone was induced by PMA. Vanadates 0-8 mitogen-activated protein kinase 8 Homo sapiens 122-157 10400652-2 1999 Treatment of macrophages with vanadate results in the activation of both NF-kappaB and c-Jun N-terminal kinase (JNK). Vanadates 30-38 mitogen-activated protein kinase 8 Homo sapiens 87-110 10400652-2 1999 Treatment of macrophages with vanadate results in the activation of both NF-kappaB and c-Jun N-terminal kinase (JNK). Vanadates 30-38 mitogen-activated protein kinase 8 Homo sapiens 112-115 10085098-8 1999 Hence, treatment of Bcl-xL cells with sodium vanadate, a tyrosine phosphatase inhibitor, restores MMS-induced activation of RAFTK and JNK. Vanadates 38-53 mitogen-activated protein kinase 8 Homo sapiens 134-137 10400652-6 1999 Conversely, blockage of JNK activation by transfection of a kinase-inactive form of SEK1 resulted in partially inhibition of vanadate-induced IkappaBalpha degradation. Vanadates 125-133 mitogen-activated protein kinase 8 Homo sapiens 24-27 10400652-7 1999 Both vanadate-induced degradation of IkappaBalpha and activation of JNK were potently inhibited by pretreatment of cells with N-acetylcysteine or dimercaprol. Vanadates 5-13 mitogen-activated protein kinase 8 Homo sapiens 68-71 10400652-8 1999 These results demonstrate that early activation of stress kinases or change of cellular redox states plays a key role in vanadate-induced activation of NF-kappaB and JNK. Vanadates 121-129 mitogen-activated protein kinase 8 Homo sapiens 166-169 10343170-6 1999 In this study we confirm these results and show that the protein tyrosine phosphatase inhibitor sodium vanadate activates ERK, JNK and Akt/PKB, but does not stimulate proliferation. Vanadates 96-111 mitogen-activated protein kinase 8 Homo sapiens 127-130