PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16300728-4	2006	Here, we found that exposure of A549 human lung carcinoma cells to vanadate led to extracellular signal-regulated kinase, c-Jun NH(2)-terminal protein kinases (JNKs), p38 mitogen-activated protein kinase (p38) activation, and COX-2 protein expression in a dose-dependent manner.	Vanadates	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231	
10595652-1	1999	Our previous study showed that vanadate, an inhibitor of protein tyrosine phosphatases, induced the expression of cyclo-oxygenase (COX)-2 in a protein-tyrosine-kinase (PTK)-dependent manner in human umbilical vein endothelial cells (HUVEC).	Vanadates	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-137	
10595652-2	1999	Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC.	Vanadates	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154	
10595652-5	1999	Either tyrphostin-47, PD98059, a specific inhibitor of the upstream kinase toward ERK1/2, or SB203580, a specific inhibitor of p38, completely suppressed vanadate-induction of COX-2 mRNA and protein.	Vanadates	154-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181	
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Vanadates	226-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74	
16300728-0	2006	Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway.	Vanadates	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18	
9065752-3	1997	Vanadate also stimulated an increase in COX-2 protein levels, but did not affect significantly the levels of constitutively expressed COX-1 protein.	Vanadates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45	
18810744-5	2008	Contrary to 1 a and 1 b, in 2 a and 2 b the vanadate chains link Co(II) cations to generate 3D chiral inorganic skeletons, which are assembled from two kinds of heterometallic helical units of opposite chirality along the c axes.	Vanadates	44-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71	
16300728-6	2006	Furthermore, the epithelial growth factor (EGF) receptor specific inhibitor (PD153035) reduced vanadate-induced COX-2 expression.	Vanadates	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117	
16300728-8	2006	Together, we suggested that EGF receptor and p38 MAPK signaling pathway may be involved in vanadate-induced COX-2 protein expression in A549 human lung carcinoma cell line.	Vanadates	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113