PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17494643-3	2007	Vanadate-induced trapping of [alpha-(32)P]8N(3)ADP by the Pro1150Ala mutant in the absence of substrate was also greatly reduced compared with wild-type MRP1 suggesting an uncoupling of ATP hydrolysis and transport activity.	Vanadates	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	153-157	
25273023-7	2015	Furthermore, MRP1 was upregulated by the Ser/Thr phosphatase inhibitor okadaic acid and downregulated by the tyrosine phosphatase inhibitor vanadate, suggesting that MRP1 protein was stabilized by p-Ser GSK3alphabeta.	Vanadates	140-148	ATP binding cassette subfamily C member 1	Homo sapiens	13-17	
25273023-7	2015	Furthermore, MRP1 was upregulated by the Ser/Thr phosphatase inhibitor okadaic acid and downregulated by the tyrosine phosphatase inhibitor vanadate, suggesting that MRP1 protein was stabilized by p-Ser GSK3alphabeta.	Vanadates	140-148	ATP binding cassette subfamily C member 1	Homo sapiens	166-170	
11543717-5	2001	This may be because cancer cells are able to overexpress multidrug resistance-associated protein (Mg(2+)-dependent vanadate-sensitive GS-conjugate export ATPase, MRP/GS-X pump), which extrudes CP-PGs to the extracellular space as glutathione S-conjugates.	Vanadates	115-123	ATP binding cassette subfamily C member 1	Homo sapiens	166-170	
15252017-5	2004	However, when measuring the effect of nucleotide and transported substrates on the vanadate-induced cleavage reactions, we found that the effect of substrates on the cleavage reactions was significantly different in the mutant MRP1 proteins than in the wild type.	Vanadates	83-91	ATP binding cassette subfamily C member 1	Homo sapiens	227-231	
15208328-10	2004	Furthermore, vanadate-induced trapping of azido-ADP by E1204L was dramatically increased, indicating that this mutation may cause a partial uncoupling of the catalytic and transport activities of MRP1.	Vanadates	13-21	ATP binding cassette subfamily C member 1	Homo sapiens	196-200	
11448450-7	2001	Incubation of CCRF-CEM/E1000 cells in 25 mM glutathione not only showed that verapamil-mediated efflux occurred against the concentration gradient, but also demonstrated the MRP1-mediated uptake of glutathione (P < 0.01 compared to the parental CCRF-CEM cells), which was not inhibited by vanadate.	Vanadates	292-300	ATP binding cassette subfamily C member 1	Homo sapiens	174-178	
11444977-9	2001	Under hydrolysis conditions (at 37 degrees C), orthovanadate induces trapping of the 8-azido[alpha-(32)P]nucleotide in MRP1, which can be further modulated by known MRP1 ligands.	Vanadates	47-60	ATP binding cassette subfamily C member 1	Homo sapiens	119-123	
11444977-9	2001	Under hydrolysis conditions (at 37 degrees C), orthovanadate induces trapping of the 8-azido[alpha-(32)P]nucleotide in MRP1, which can be further modulated by known MRP1 ligands.	Vanadates	47-60	ATP binding cassette subfamily C member 1	Homo sapiens	165-169	
9762421-3	1998	Mg(2+)-dependent vanadate-sensitive glutathione S-conjugate ATPase (GS-X pump) activity is a common feature of some ATP-binding cassette (ABC) transporters, such as the multidrug resistance-associated protein (MRP1) gene product, that exports biologically active electrophiles after their conjugation with intracellular glutathione (GSH) from normal and cancer cells.	Vanadates	17-25	ATP binding cassette subfamily C member 1	Homo sapiens	68-72	
9762421-3	1998	Mg(2+)-dependent vanadate-sensitive glutathione S-conjugate ATPase (GS-X pump) activity is a common feature of some ATP-binding cassette (ABC) transporters, such as the multidrug resistance-associated protein (MRP1) gene product, that exports biologically active electrophiles after their conjugation with intracellular glutathione (GSH) from normal and cancer cells.	Vanadates	17-25	ATP binding cassette subfamily C member 1	Homo sapiens	169-214