PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15276086-1	2004	P-glycoprotein (PGP) substrates with high membrane permeability, such as propranolol and verapamil, are considered to be essentially "transparent" to PGP since the transporter does not significantly limit their absorption or elimination.	Propranolol	73-84	ATP binding cassette subfamily B member 1	Homo sapiens	0-14	
15276086-1	2004	P-glycoprotein (PGP) substrates with high membrane permeability, such as propranolol and verapamil, are considered to be essentially "transparent" to PGP since the transporter does not significantly limit their absorption or elimination.	Propranolol	73-84	ATP binding cassette subfamily B member 1	Homo sapiens	16-19	
15276086-7	2004	The induction of PGP by propranolol and verapamil was rapid with significant increases occurring within 3h with maximal stimulation after 6h exposure.	Propranolol	24-35	ATP binding cassette subfamily B member 1	Homo sapiens	17-20	
15276086-9	2004	In conclusion, verapamil and propranolol, whose trans-epithelial permeability are unaffected by PGP, appear to be effective inducers of PGP expression in gut epithelial cells in vitro.	Propranolol	29-40	ATP binding cassette subfamily B member 1	Homo sapiens	136-139	
14744938-8	2004	Next, erythromycin and propranolol were explored as positive and negative control substrates for Pgp/CYP3A interactions, respectively.	Propranolol	23-34	ATP binding cassette subfamily B member 1	Homo sapiens	97-100	
19380024-4	2009	The mRNA expression of the ABCB1 gene (previously MDR1) in human colon carcinoma HT-29 cell line was measured after treatment with an adrenergic receptor agonist (adrenaline) and various antagonists (propranolol, prazosin, and yohimbine).	Propranolol	200-211	ATP binding cassette subfamily B member 1	Homo sapiens	27-32	
15023456-2	2004	Propranolol is a poorly soluble drug and known substrate of the P-glycoprotein (P-gp) efflux transporter.	Propranolol	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	64-78	
15023456-2	2004	Propranolol is a poorly soluble drug and known substrate of the P-glycoprotein (P-gp) efflux transporter.	Propranolol	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	80-84	
11576779-7	2001	The most hydrophobic beta-ligand, propranolol, a known Pgp substrate, gave the largest increase in Rh123 accumulation in this therapeutic class.	Propranolol	34-45	ATP binding cassette subfamily B member 1	Homo sapiens	55-58	
19672719-7	2009	Also, the absorption of various drugs such as propranolol through P-glycoprotein (P-gp) efflux transporter is low and erratic.	Propranolol	46-57	ATP binding cassette subfamily B member 1	Homo sapiens	66-80	
19672719-7	2009	Also, the absorption of various drugs such as propranolol through P-glycoprotein (P-gp) efflux transporter is low and erratic.	Propranolol	46-57	ATP binding cassette subfamily B member 1	Homo sapiens	82-86	
16671962-4	2006	Therefore, we investigated the P-glycoprotein-mediated transport of propranolol, metoprolol, bisoprolol, carvedilol and sotalol in P-glycoprotein-expressing Caco-2 monolayers and inhibition of P-glycoprotein-mediated digoxin transport by the beta-adrenoceptor antagonists.	Propranolol	68-79	ATP binding cassette subfamily B member 1	Homo sapiens	31-45	
16671962-6	2006	Moreover, propranolol and carvedilol inhibited P-glycoprotein-mediated digoxin transport with IC(50) values of 24.8 and 0.16 microm, respectively, whereas metoprolol and sotalol had no effect.	Propranolol	10-21	ATP binding cassette subfamily B member 1	Homo sapiens	47-61	
16671962-9	2006	In addition, the beta-adrenoceptor antagonists propranolol and carvedilol significantly inhibit P-glycoprotein function thereby possibly contributing to drug interactions in humans (e.g. digoxin-carvedilol and cyclosporine-carvedilol).	Propranolol	47-58	ATP binding cassette subfamily B member 1	Homo sapiens	96-110