PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10092983-5	1999	This ET-1-reducing effect was even more pronounced in thrombin-stimulated cells (10(-5) mol L-1 of propranolol, metoprolol and celiprolol: 19% +/- 5.8%, 25% +/- 4% and 37% +/- 5.2% respectively).	Propranolol	99-110	coagulation factor II, thrombin	Homo sapiens	54-62	
7619088-5	1995	These data suggest that propranolol inhibits signal transduction in thrombin-stimulated platelets by interacting at the level of phospholipase C and exclude interaction of the drug with the downstream effector enzyme protein kinase C.	Propranolol	24-35	coagulation factor II, thrombin	Homo sapiens	68-76	
9547558-0	1997	Dual effect of propranolol on the human platelet activation by thrombin: potentiation of free intracellular Ca2+ mobilization and inhibition of phospholipase D activity.	Propranolol	15-26	coagulation factor II, thrombin	Homo sapiens	63-71	
8724032-1	1996	We report the case of a patient who developed jaundice, encephalopathy, a marked increase in serum aminotransferase activity and a decrease in prothrombin and proaccelerin levels, after 6 weeks" treatment with carbimazole and propranolol for hyperthyroidism.	Propranolol	226-237	coagulation factor II, thrombin	Homo sapiens	143-154	
6118758-1	1981	Treatment of hypertensive patients with dl-propranolol (640 mg/day) significantly inhibited thromboxane synthesis by their platelets and platelet aggregation induced by thrombin or arachidonic acid.	Propranolol	40-54	coagulation factor II, thrombin	Homo sapiens	169-177	
2571198-1	1989	The dose-dependent inhibition of thrombin stimulated platelet aggregation due to beta-adrenoceptor blocking drugs followed the rank order of potency: propranolol greater than alprenolol greater than metipranolol and correlated with arachidonic acid (3H-AA) liberation.	Propranolol	150-161	coagulation factor II, thrombin	Homo sapiens	33-41	
2525784-3	1989	The results indicate that propranolol at concentrations near the therapeutic range, significantly inhibit collagen and thrombin-induced platelet aggregation and TxB2 synthesis from PRP.	Propranolol	26-37	coagulation factor II, thrombin	Homo sapiens	119-127	
22571264-6	2012	Pretreatment of platelets with 1-butanol significantly attenuated thrombin-induced increase in [Ca2+](i) , while thrombin-induced increase in [Ca2+](i) was augmented in the presence of propranolol.	Propranolol	185-196	coagulation factor II, thrombin	Homo sapiens	113-121	
318874-5	1977	At higher concentrations (10-50 muM), propranolol abolished the second wave of platelet aggregation induced by ADP and epinephrine, and inhibited aggregation induced by collagen, thrombin, and the ionophore A23187.	Propranolol	38-49	coagulation factor II, thrombin	Homo sapiens	179-187	
15869009-9	2005	RESULTS: Carvedilol and propranolol inhibited platelet aggregation in the rank order of stimuli: PMA > thrombin > A23187 > epinephrine.	Propranolol	24-35	coagulation factor II, thrombin	Homo sapiens	106-114