PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11373471-7 2001 MEASUREMENTS AND MAIN RESULTS: Epinephrine and norepinephrine increased the production of IL-6 but not of IL-1alpha in normal abdominal skin, and these increases were reversed by a beta-blocker (propranolol hydrochloride) but not an alpha-blocker (phentolamine mesylate). Propranolol 195-220 interleukin 6 Mus musculus 90-94 17118511-7 2007 RESULTS: Administration of propranolol in septic mice increased the splenocyte apoptosis rate, reduced the proliferative capacity of splenocytes, and modulated cellular cytokine release (IL-6, IFN-gamma). Propranolol 27-38 interleukin 6 Mus musculus 187-191 14722032-7 2004 Epinephrine-stimulated IL-6 expression was attenuated by the alpha-adrenergic receptor antagonist phentolamine and completely blocked by either the beta1/2-adrenergic receptor antagonist propranalol or the beta2-antagonist ICI-118551. Propranolol 187-198 interleukin 6 Mus musculus 23-27 15084649-6 2004 Propranolol, but not ODQ, suppressed the inhibitory activity of NCX-950 on neutrophil influx and IL-6 release in BAL fluids. Propranolol 0-11 interleukin 6 Mus musculus 97-101 15249727-7 2004 Treatment with propranolol augmented the epinephrine-induced increase of splenocyte apoptosis, did not affect the decrease of splenocyte proliferation and IL-2 release, augmented the release of IL-6 and antagonized the mobilization of natural killer cells observed in epinephrine-treated animals. Propranolol 15-26 interleukin 6 Mus musculus 194-198 15249727-9 2004 Coadministration of propranolol and epinephrine augmented the propranolol-induced changes of splenocyte apoptosis and IL-6 release and was associated with the highest mortality of septic mice. Propranolol 20-31 interleukin 6 Mus musculus 118-122 15249727-9 2004 Coadministration of propranolol and epinephrine augmented the propranolol-induced changes of splenocyte apoptosis and IL-6 release and was associated with the highest mortality of septic mice. Propranolol 62-73 interleukin 6 Mus musculus 118-122 12900383-8 2003 Furthermore, pretreatment with a beta-blocker, propranolol (15 or 25 mg/kg ip), inhibited both stress- and LPS-induced increases in the level of IL-6 mRNA, but pretreatment with an alpha-blocker, phentolamine (5 mg/kg sc), did not inhibit them in mouse calvaria. Propranolol 47-58 interleukin 6 Mus musculus 145-149 9281306-6 1997 Propranolol, a phosphatidic acid phosphohydrolase inhibitor, enhanced the IL-6 synthesis by thrombin. Propranolol 0-11 interleukin 6 Mus musculus 74-78 10582659-6 1999 In addition, U-73122, an inhibitor of phospholipase C, and propranolol, a phosphatidic acid phosphohydrolase inhibitor, enhanced the PGD2-induced IL-6 synthesis. Propranolol 59-70 interleukin 6 Mus musculus 146-150 31800964-2 2019 We previously showed that propranolol reduces choroidal neovascularization (CNV) by decreasing interleukin-6 levels. Propranolol 26-37 interleukin 6 Mus musculus 95-108 9376229-11 1997 Propranolol, a phosphatidic acid phosphohydrolase inhibitor, also enhanced the IL-6 synthesis by bFGF. Propranolol 0-11 interleukin 6 Mus musculus 79-83 8982101-3 1996 We demonstrated that under septic-like conditions in the presence of bacteria and lipopolysaccharide (LPS), electrically induced inhibition of interleukin 6 (IL-6) secretion was attenuated by the beta-adrenergic antagonist propranolol. Propranolol 223-234 interleukin 6 Mus musculus 143-156 8982101-3 1996 We demonstrated that under septic-like conditions in the presence of bacteria and lipopolysaccharide (LPS), electrically induced inhibition of interleukin 6 (IL-6) secretion was attenuated by the beta-adrenergic antagonist propranolol. Propranolol 223-234 interleukin 6 Mus musculus 158-162 34858728-10 2021 Further study revealed that the expressions of IL-6 and JAK/STAT3 signaling pathways were upregulated by chronic stress in mice, and this upregulation could be inhibited by propranolol. Propranolol 173-184 interleukin 6 Mus musculus 47-51 34858728-12 2021 Besides, propranolol inhibited the expression of IL-6 in supernatant of 4T1 cells induced by isoproterenol and reduced the proportion of inducible MDSCs in vitro. Propranolol 9-20 interleukin 6 Mus musculus 49-53 28539257-8 2017 In addition, beta-blocker propranolol prevented the NF-kB nuclear translocation and the increase in phospho-IkappaB-alpha (Ser32) and in interleukin(IL)-6 expression in aorta of obese mice, without significant changes in either aortic reactive oxygen species production or in circulating IL-6 and TNF-alpha levels. Propranolol 26-37 interleukin 6 Mus musculus 137-154 28539257-8 2017 In addition, beta-blocker propranolol prevented the NF-kB nuclear translocation and the increase in phospho-IkappaB-alpha (Ser32) and in interleukin(IL)-6 expression in aorta of obese mice, without significant changes in either aortic reactive oxygen species production or in circulating IL-6 and TNF-alpha levels. Propranolol 26-37 interleukin 6 Mus musculus 288-292 18421015-5 2008 Propranolol inhalation resulted in enhanced LPS-induced lung inflammation, which was reflected by a stronger secretion of TNF-alpha, IL-6, and monocyte chemoattractant protein-1 into BALF and by enhanced coagulation activation (thrombin-antithrombin complexes). Propranolol 0-11 interleukin 6 Mus musculus 133-137 22841997-8 2012 In addition to anxiety-like behavior the SDR induced splenomegaly and increase in plasma IL-6, TNFalpha, and MCP-1 were each reversed by pre-treatment with propranolol. Propranolol 156-167 interleukin 6 Mus musculus 89-93 22841997-10 2012 In addition, supernatants from 18h LPS-stimulated ex vivo cultures of splenocytes from propranolol-treated SDR mice contained less IL-6. Propranolol 87-98 interleukin 6 Mus musculus 131-135