PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23528058-0 2013 Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147. Propranolol 0-11 basigin (Ok blood group) Homo sapiens 98-103 23528058-5 2013 OBJECTIVES: To investigate the role of CD147 in propranolol-induced apoptosis in human umbilical vein endothelial cells (HUVECs). Propranolol 48-59 basigin (Ok blood group) Homo sapiens 39-44 23528058-14 2013 Knocking down CD147 not only induced apoptosis but also exacerbated the apoptosis triggered by propranolol in HUVECs. Propranolol 95-106 basigin (Ok blood group) Homo sapiens 14-19 23528058-15 2013 Overexpression of CD147 can protect HUVECs from apoptosis and propranolol-induced apoptosis. Propranolol 62-73 basigin (Ok blood group) Homo sapiens 18-23 23528058-16 2013 Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway. Propranolol 31-42 basigin (Ok blood group) Homo sapiens 133-138 23528058-16 2013 Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway. Propranolol 117-128 basigin (Ok blood group) Homo sapiens 47-52 23528058-17 2013 CONCLUSIONS: Our studies demonstrate that propranolol-induced apoptosis may be mediated through the downregulation of CD147 in HUVECs. Propranolol 42-53 basigin (Ok blood group) Homo sapiens 118-123