PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9116917-3 1997 D.L.-Propranolol hydrochloride (propranolol), an inhibitor of phosphatidic acid phosphohydrolase, significantly inhibited the Ang II-induced release of AA metabolites. Propranolol 32-43 angiotensinogen Rattus norvegicus 126-132 9116917-7 1997 Both propranolol and RHC-80267 inhibited the Ang II-induced synthesis of 6-keto-prostaglandin F1 alpha, a stable metabolite of prostacyclin. Propranolol 5-16 angiotensinogen Rattus norvegicus 45-51 7869608-5 1994 In addition, the Ang II (1 nmol)-induced antidiuretic effects were partially inhibited by phenoxybenzamine (80 nmol) in the SON and by phenoxybenzamine, timolol (100 nmol) and propranolol (100 nmol) in the PVN. Propranolol 176-187 angiotensinogen Rattus norvegicus 17-23 7723353-5 1995 The effect of AII was not influenced by propranolol 10(-6) M or phentolamine 10(-7) M but was blocked by 250 microM DuP 753. Propranolol 40-51 angiotensinogen Rattus norvegicus 14-17 7908853-3 1994 Propranolol (a nonselective beta-adrenoceptor blocker) antagonized the water ingestion and enhanced the Na+, and urine excretion induced by ANGII. Propranolol 0-11 angiotensinogen Rattus norvegicus 140-145 8103195-4 1993 After treatment with propranolol, the positive chronotropic effect of angiotensin II was abolished. Propranolol 21-32 angiotensinogen Rattus norvegicus 70-84 8103195-6 1993 When aortic blood pressure was controlled and the beta-receptors were blocked by propranolol, angiotensin II caused a dose-dependent increase in dP/dtmax without affecting the left ventricular enddiastolic pressure. Propranolol 81-92 angiotensinogen Rattus norvegicus 94-108 2545988-4 1989 Propranolol (10(-7) M) completely inhibited the ability of epinephrine to augment the stimulatory actions of AII. Propranolol 0-11 angiotensinogen Rattus norvegicus 109-112 2260972-9 1990 The stimulatory effect by 10(-9) M HgCl2 in 10(-11) M ANG II-induced [Ca++]i increase was completely inhibited by propranolol. Propranolol 114-125 angiotensinogen Rattus norvegicus 54-60 2260972-10 1990 Moreover, 10(-4) M propranolol completely blocked the stimulatory effect of HgCl2 on ANG II-mediated IP3 production. Propranolol 19-30 angiotensinogen Rattus norvegicus 85-91 3346050-9 1988 The effect of beta-adrenergic modulation on the release of angiotensin II was assessed in 20 rats by adding isoproterenol (10(-10), 10(-8), and 10(-6) M), propranolol (10(-6) M), or a combination of both. Propranolol 155-166 angiotensinogen Rattus norvegicus 59-73 2840395-4 1988 We also examined the effects of isoproterenol and propranolol on the immunoreactive Ang I and II release. Propranolol 50-61 angiotensinogen Rattus norvegicus 84-96 2840395-7 1988 Isoproterenol (10(-6) M) failed to cause a change in the release of both peptides, but propranolol (10(-6) M) slightly decreased the release of immunoreactive Ang I and II by 28 +/- 4% (p less than 0.001) and 32 +/- 4% (p less than 0.001), respectively. Propranolol 87-98 angiotensinogen Rattus norvegicus 159-171 2840395-8 1988 There was a highly significant positive correlation between the released amount of immunoreactive Ang I and that of immunoreactive Ang II altered by indomethacin (r = 0.91), meclofenamate (r = 0.94), or propranolol administration (r = 0.90). Propranolol 203-214 angiotensinogen Rattus norvegicus 131-137 3002196-10 1986 The increase in ANG II release during isoproterenol (10(-6) M) infusion was blocked by propranolol (10(-6) M). Propranolol 87-98 angiotensinogen Rattus norvegicus 16-22 3023020-6 1986 beta-Receptor blockade with propranolol potentiated both NE- and AII-induced LH release. Propranolol 28-39 angiotensinogen Rattus norvegicus 65-68 6313393-6 1983 In like manner, supersensitivity to the vasorelaxant action of isoproterenol was demonstrated in aortic strips precontracted with angiotensin II at 72 and 96 h after propranolol withdrawal. Propranolol 166-177 angiotensinogen Rattus norvegicus 130-144 3884574-5 1985 Treatment with ANG II (200 micrograms/kg sc) and propranolol, a beta-adrenoceptor antagonist (6 mg/kg ip), resulted in a greater depression of colonic temperature (Tco) than was observed with ANG II alone but did not affect the increase in tail skin temperature (Tsk) accompanying administration of ANG II. Propranolol 49-60 angiotensinogen Rattus norvegicus 192-198 3884574-5 1985 Treatment with ANG II (200 micrograms/kg sc) and propranolol, a beta-adrenoceptor antagonist (6 mg/kg ip), resulted in a greater depression of colonic temperature (Tco) than was observed with ANG II alone but did not affect the increase in tail skin temperature (Tsk) accompanying administration of ANG II. Propranolol 49-60 angiotensinogen Rattus norvegicus 192-198 29162996-7 2017 While losartan or captopril with propranolol potentiated bradykinin-induced vasodilation effect, the propranolol-losartan interaction decreased the angiotensin II-induced vasoconstriction. Propranolol 101-112 angiotensinogen Rattus norvegicus 148-162 6131020-7 1982 SH rats treated with propranolol showed a leftward shift of the pressor response curve not to norepinephrine but to angiotensin II as compared with that obtained from vehicle treated SH rats. Propranolol 21-32 angiotensinogen Rattus norvegicus 116-130 6259059-0 1981 A possible antihypertensive mechanism of propranolol: antagonism of angiotensin II enhancement of sympathetic nerve transmission through prostaglandins. Propranolol 41-52 angiotensinogen Rattus norvegicus 68-82 6259059-3 1981 The dl-propranolol had no effect on the basal vasoconstrictor responses to NS and NE, yet inhibited the AII-enhanced vasoconstrictor responses to NS by 47% (p less than 0.05) and 81% (p less than 0.001) at 100 and 300 ng/ml respectively. Propranolol 4-18 angiotensinogen Rattus norvegicus 104-107 6259059-5 1981 A similar blockade of AII enhancement of NS was observed with the d-isomer of propranolol. Propranolol 78-89 angiotensinogen Rattus norvegicus 22-25 6259059-7 1981 Indomethacin, a prostaglandin synthetase inhibitor (5 mg/kg, s.c.), abolished the inhibitory effect of dl-propranolol on AII enhancement of NS. Propranolol 103-117 angiotensinogen Rattus norvegicus 121-124 6259059-10 1981 We conclude that propranolol antagonizes AII enhancement of NS by increasing prostaglandin levels in vascular tissue. Propranolol 17-28 angiotensinogen Rattus norvegicus 41-44 6102965-6 1980 At the 100 ng/ml concentration, DL-propranolol, timolol, metoprolol, practolol, butoxamine, and H35/25 inhibited the angiotensin II potentiation of NS by 83%, 76%, 77%, 59%, 72%, and 41% respectively. Propranolol 32-46 angiotensinogen Rattus norvegicus 117-131 859212-6 1977 The involvements of adrenergic mechanism in the central pressor effect of angiotensin II were studied through observation of blood pressure changes following injection of angiotensin II, phentolamine and propranolol into the rabbit lateral ventricle of rabbit brain. Propranolol 204-215 angiotensinogen Rattus norvegicus 74-88 20147605-7 2010 In the presence of 10(-5) M propranolol, the effect of norepinephrine to prevent the inhibition of chloride transport by ANG II was still present. Propranolol 28-39 angiotensinogen Rattus norvegicus 121-127 18445492-8 2008 Furthermore, the protective effect of Ang II on GI-R injury was abolished by propranolol (1 mg/kg, i.v.) Propranolol 77-88 angiotensinogen Rattus norvegicus 38-44 9635150-1 1998 The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstriction. Propranolol 269-286 angiotensinogen Rattus norvegicus 45-59 9635150-1 1998 The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstriction. Propranolol 269-286 angiotensinogen Rattus norvegicus 61-64 10666319-9 2000 Propranolol (100 nM-10 microM), which inhibits PA phosphohydrolase, blocked the growth stimulated by Ang II, PLD, or PA by as much as 95%, an effect not shared by other beta-adrenergic antagonists. Propranolol 0-11 angiotensinogen Rattus norvegicus 101-107 10666319-10 2000 Propranolol also increased the production of PA in the presence of Ang II by 320% and reduced DAG and arachidonic acid (AA) accumulation. Propranolol 0-11 angiotensinogen Rattus norvegicus 67-73 9712176-5 1998 (4) Treatment with propranolol (beta-adrenoceptor blocker, 1 mg/kg body weight) did not reduce the vagus effects alone, but decreased the modulatory AII effects. Propranolol 19-30 angiotensinogen Rattus norvegicus 149-152 9401758-12 1997 However, the AII-evoked femoral vasodilatation was not due to an autonomic or neuroendocrine reflex because it was not depressed by hexamethonium (75 mumol kg-1), prazosin (0.25 mumol kg-1) or propranolol (3 mumol kg-1). Propranolol 193-204 angiotensinogen Rattus norvegicus 13-16 9315342-5 1997 Similarly, 100 microM (+/-)-propranolol (a dose likely to cause plasma membrane stabilizing effects involving interruption and (or) prevention of action potentials) blocked increases in VO2, lactate, and glycerol efflux by 5 nM angiotensin II (a nonadrenergic vasoconstrictor) with only marginal effects on pressure development. Propranolol 22-39 angiotensinogen Rattus norvegicus 228-242