PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23217879-11	2012	We also demonstrated activation of the caspase cascade, including caspase-9 and caspase-3 of the intrinsic pathway, and an increased p53 gene expression and Bax/Bcl-xL ratio in HemECs treated with 100 muM propranolol.	Propranolol	205-216	caspase 3	Homo sapiens	80-89	
34721024-7	2021	Western blotting showed that cotreatment significantly enhanced the expression of cleaved caspase-3 in HCT116 and MC38 cells compared with the propranolol or T1012G alone.	Propranolol	143-154	caspase 3	Homo sapiens	90-99	
35266887-12	2022	Propranolol treatment elevated the activity of caspase-3 and expression of bax, Wee1, GADD153 and apoptosis-inducing factor, but decreased bcl-2 which is an antiapoptotic protein.	Propranolol	0-11	caspase 3	Homo sapiens	47-56	
33164541-10	2020	It was found that propranolol treatment enhanced the activity of caspase-3 while the expression of bax, wee1, gadd153, grp78 and AIF decreased bcl-2 which is antiapoptotic protein in cSCC cell lines.	Propranolol	18-29	caspase 3	Homo sapiens	65-74	
28848082-9	2017	The expression of caspase 3/7, 8, and 9 was elevated in propranolol-treated myeloma cells.	Propranolol	56-67	caspase 3	Homo sapiens	18-39	
35088452-9	2022	We found that exposure to propranolol either by combination with carbachol facilitates additive effects on inhibition of caspase 3 and 8 expression in chronic myeloid leukemia K562 cells.	Propranolol	26-37	caspase 3	Homo sapiens	121-136	
32922532-7	2020	What is more, p38 inhibitor SB203580 and JNK inhibitor SP600125 attenuated the upregulated expression of LC3-II and cleaved-caspase-3 by the effect of Propranolol.	Propranolol	151-162	caspase 3	Homo sapiens	124-133	
29393410-11	2018	Propranolol promoted poly (ADP-ribose) polymerase cleavage and decreased the expression of full-length caspase-3 in liver cancer cell lines; it induced S-phase arrest in HepG2 and HepG2.2.15 cell lines, while HL-7702 cells were arrested at the G0/G1 phase of the cell cycle.	Propranolol	0-11	caspase 3	Homo sapiens	103-112	
28279700-0	2017	Molecular and immunohistochemical expression of apoptotic proteins Bax, Bcl-2 and Caspase 3 in infantile hemangioma tissues as an effect of propranolol treatment.	Propranolol	140-151	caspase 3	Homo sapiens	82-91	
24137229-7	2013	Gene expression analyses revealed that propranolol treatment led to a marked increase in the expression of caspase-8, cytochrome c, apoptosis-inducing factor, caspase-3 and poly (ADP-ribose) polymerase 1, as well as a concomitant reduction in lamin B1 expression.	Propranolol	39-50	caspase 3	Homo sapiens	159-203	
23080133-4	2013	METHODS: Time-dependent antiproliferation and apoptotic effects of propranolol were subsequently determined by MTT cell proliferation assay, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP), and also the localization of phosphatidylserine in the plasma membrane.	Propranolol	67-78	caspase 3	Homo sapiens	152-161	
23080133-7	2013	There were significant increases in caspase-3 activity, loss of MMP, and increases in apoptotic cell population in response to propranolol in U266 cells in a time- and dose-dependent manner.	Propranolol	127-138	caspase 3	Homo sapiens	36-45	
18534571-4	2008	Propranolol and ICI 118551, but not atenolol, demonstrated a concentration-dependent inhibition of caspase 3-like activity.	Propranolol	0-11	caspase 3	Homo sapiens	99-108