PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9435911-1	1997	Although the beta-adrenergic antagonist propranolol (1) binds at rodent 5-HT1B serotonin receptors, it displays low affinity (Ki > 10,000 nM) for its species homologue 5-HT1D beta (i.e., h5-HT1B) receptors.	Propranolol	40-51	5-hydroxytryptamine receptor 1B	Homo sapiens	171-182	
8569707-3	1996	However, the specific involvement of the propranolol oxygen atoms in binding to the wild-type and T355N mutant 5-HT1D beta receptors has never been addressed experimentally.	Propranolol	41-52	5-hydroxytryptamine receptor 1B	Homo sapiens	111-122	
8569707-5	1996	Propranolol was docked with the wild-type and T355N mutant 5-HT1D beta receptor models in an attempt to understand the difference in affinity of the ligand for the receptors.	Propranolol	0-11	5-hydroxytryptamine receptor 1B	Homo sapiens	59-70	
2539480-3	1989	The beta-adrenergic antagonist propranolol binds stereoselectively both at 5-HT1A and 5-HT1B sites (with a several-fold selectivity for the latter) and, whereas it is a 5-HT1A antagonist, it appears to be a 5-HT1B agonist.	Propranolol	31-42	5-hydroxytryptamine receptor 1B	Homo sapiens	86-92	
2539480-5	1989	The purpose of the present study was to modify the structure of propranolol in such a manner so as to reduce its affinity for 5-HT1B and beta-adrenergic sites while, at the same time, retaining its affinity for 5-HT1A sites.	Propranolol	64-75	5-hydroxytryptamine receptor 1B	Homo sapiens	126-132	
2539480-6	1989	Removal of the side-chain hydroxyl group of propranolol, and conversion of its secondary amine to a tertiary amine, reduced affinity for 5-HT1B and beta-adrenergic sites.	Propranolol	44-55	5-hydroxytryptamine receptor 1B	Homo sapiens	137-143