PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25837585-6	2015	These effects on the BODIPY-TMR-CGP dissociation rate were markedly enhanced in beta1-adrenoceptor homodimers constrained by bimolecular fluorescence complementation (9.8- and 9.9-fold for 1 microM CGP 12177 and 1 microM propranolol, respectively) and abolished in beta1-adrenoceptors containing TM4 mutations vital for the second conformation pharmacology.	Propranolol	221-232	adrenoceptor beta 1	Homo sapiens	80-98	
30153111-8	2018	We took advantage of the beta1-AR selectivity gradient of these drugs (propranolol [nonselective] << atenolol [relatively beta1-AR selective] < nebivolol [highly beta1-AR selective]) to define the beta-AR selectivity for SNS effects on bone.	Propranolol	71-82	adrenoceptor beta 1	Homo sapiens	25-33	
26574555-3	2016	Propranolol is a nonselective beta-adrenergic receptor (betaAR) antagonist that can lower cAMP levels and activate the mitogen-activated protein kinase (MAPK) pathway downstream of betaARs.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	56-62	
26574555-7	2016	Propranolol at >=10(-5) M reduced cAMP levels and activated ERK1/2, and this correlated with HemSC apoptosis and cytotoxicity at >=10(-4) M. Stimulation with a betaAR agonist, isoprenaline, promoted HemSC proliferation and rescued the antiproliferative effects of propranolol, suggesting that propranolol inhibits betaAR signaling in HemSCs.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	166-172	
26574555-7	2016	Propranolol at >=10(-5) M reduced cAMP levels and activated ERK1/2, and this correlated with HemSC apoptosis and cytotoxicity at >=10(-4) M. Stimulation with a betaAR agonist, isoprenaline, promoted HemSC proliferation and rescued the antiproliferative effects of propranolol, suggesting that propranolol inhibits betaAR signaling in HemSCs.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	320-326	
29476776-2	2018	Propranolol, a nonspecific beta1-, beta2-adrenergic receptor (AR) inverse agonist, counters the hypermetabolic response to elevated catecholamines and may decrease hypertrophic scarring by an unknown mechanism.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	27-60	
27133786-8	2016	The beta1-AR/beta2-AR inhibitor propranolol reduced the numbers of the neutrophils in the circulation, suppressed neutrophil infiltration into colonic tissues, and attenuated the colonic tissue damage promoted by chronic stress.	Propranolol	32-43	adrenoceptor beta 1	Homo sapiens	4-12	
26574555-14	2016	Propranolol, a nonselective beta-adrenergic receptor (betaAR) antagonist, has proven efficacy; however, understanding of its mechanism of action on HemSCs is limited.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	54-60	
26574555-15	2016	The presented data demonstrate that propranolol, via betaAR perturbation, dose dependently suppresses cAMP levels and activated extracellular signal-regulated kinase 1/2.	Propranolol	36-47	adrenoceptor beta 1	Homo sapiens	53-59	
26139101-8	2015	The -logKB values were 8.12 +- 0.17, 8.03 +- 0.05 and 7.23 +- 0.05 for propranolol, ICI 118551 and atenolol, respectively, indicating the possible involvement of both beta1- and beta2-adrenoceptor subtypes.	Propranolol	71-82	adrenoceptor beta 1	Homo sapiens	167-196	
25026350-1	2014	CONTEXT: Propranolol, atenolol, and ICI118,551 are non-selective beta-adrenergic receptor (AR), beta1-AR, and beta2-AR antagonists, respectively.	Propranolol	9-20	adrenoceptor beta 1	Homo sapiens	96-104	
24389287-0	2014	Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma.	Propranolol	63-74	adrenoceptor beta 1	Homo sapiens	32-51	
24389287-3	2014	In a high-throughput screen of FDA-approved drugs we identified anti-NB activity for the nonselective beta-adrenergic receptor antagonist propranolol hydrochloride.	Propranolol	138-163	adrenoceptor beta 1	Homo sapiens	107-126	
23978104-7	2014	For propranolol, inflammation resulted in increased concentration but reduced response and down-regulation of beta1- AR.	Propranolol	4-15	adrenoceptor beta 1	Homo sapiens	110-119	
18403719-5	2008	Here, we took advantage of the fact that isoproterenol, bucindolol and propranolol (full, partial, and inverse agonists for the AC pathway, respectively) all activate MAPK through the beta1-adrenergic receptor (beta1AR) to probe such conformational-biased signaling.	Propranolol	71-82	adrenoceptor beta 1	Homo sapiens	184-209	
23370410-2	2013	Recently, propranolol, a nonselective beta1- and beta2-adrenoceptor inhibitor, was introduced into the therapy of severe proliferating IH with excellent results.	Propranolol	10-21	adrenoceptor beta 1	Homo sapiens	38-67	
22396018-4	2012	Here, we show that administration of propranolol, a nonselective beta1/2 adrenergic receptor antagonist, attenuates ER stress and JNK activation.	Propranolol	37-48	adrenoceptor beta 1	Homo sapiens	65-92	
22593501-1	2012	BACKGROUND: In a retrospective controlled study, a tumor-protective effect, regarding breast cancer, was determined for the medicines metformin and glitazone (anti-diabetics), bisoprolol, and propranolol (cardioselective beta1 adrenoceptor antagonists).	Propranolol	192-203	adrenoceptor beta 1	Homo sapiens	221-239	
18403719-5	2008	Here, we took advantage of the fact that isoproterenol, bucindolol and propranolol (full, partial, and inverse agonists for the AC pathway, respectively) all activate MAPK through the beta1-adrenergic receptor (beta1AR) to probe such conformational-biased signaling.	Propranolol	71-82	adrenoceptor beta 1	Homo sapiens	211-218	
15526107-12	2004	Involvement of an additional receptor site (e.g. the propranolol-resistant state of the beta(1)-adrenoceptor), however, cannot be excluded.	Propranolol	53-64	adrenoceptor beta 1	Homo sapiens	88-108	
12616336-0	2003	(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor.	Propranolol	108-119	adrenoceptor beta 1	Homo sapiens	143-162	
14608456-0	2003	Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors.	Propranolol	70-85	adrenoceptor beta 1	Homo sapiens	108-126	
14608456-2	2003	Recent work indicates the existence of a (-)-propranolol-resistant site of the cardiac beta(1)-adrenoceptor and we propose that it mediates the cardiostimulation evoked by (-)-pindolol.	Propranolol	41-56	adrenoceptor beta 1	Homo sapiens	87-107	
14608456-8	2003	(-)-CGP12177, known to act through the (-)-propranolol-resistant site of the beta(1)-adrenoceptor, also increased with similar potency atrial contractile force (-logEC(50)M=7.6) and cAMP at recombinant beta(1)-adrenoceptors (-logEC(50)M=7.7).	Propranolol	39-54	adrenoceptor beta 1	Homo sapiens	77-97	
14608456-12	2003	We conclude that the cardiostimulant effects of (-)-pindolol in human atrial myocardium are mediated through a (-)-propranolol-resistant site of the beta(1)-adrenoceptor with low affinity for (-)-pindolol.	Propranolol	111-126	adrenoceptor beta 1	Homo sapiens	149-169	
12616336-9	2003	Our results show that (-)-CGP 12177 increases contractility and hastens relaxation through a cyclic AMP pathway in human myocardium, consistent with mediation through a (-)-propranolol-resistant state of the beta1-adrenoceptor.	Propranolol	169-184	adrenoceptor beta 1	Homo sapiens	208-226	
12616336-1	2003	Two forms of the activated beta1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such as (-)-pindolol and (-)-CGP 12177 but is relatively insensitive to (-)-propranolol.	Propranolol	129-144	adrenoceptor beta 1	Homo sapiens	27-45	
12616336-1	2003	Two forms of the activated beta1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such as (-)-pindolol and (-)-CGP 12177 but is relatively insensitive to (-)-propranolol.	Propranolol	269-284	adrenoceptor beta 1	Homo sapiens	27-45	
12616336-2	2003	We investigated the effects of stimulation of the propranolol-resistant beta1-adrenoceptor in the human heart.	Propranolol	50-61	adrenoceptor beta 1	Homo sapiens	72-90	
7912102-5	1993	The results and conclusions were the following: (a) The extent to which metoprolol, pindolol, and propranolol occupied rabbit lung beta 1- and rat reticulocyte beta 2-adrenoceptors in plasma samples estimated accurately the intensity of beta-receptor antagonism in the patients who did not tolerate physiological and pharmacological tests measuring the degree of beta 1- and beta 2-adrenoceptor blockade.	Propranolol	98-109	adrenoceptor beta 1	Homo sapiens	363-394	
11861783-5	2002	Recently, this putative beta4-adrenoceptor has been identified to be a propranolol-insensitive state of the beta1-adrenoceptor.	Propranolol	71-82	adrenoceptor beta 1	Homo sapiens	108-126	
7599912-6	1995	Thus, in these doses bisoprolol antagonized only beta 1-adrenoceptor mediated effects, propranolol both beta 1- and beta 2-adrenoceptor mediated effects, but both antagonists had no alpha-adrenoceptor antagonistic effects.	Propranolol	87-98	adrenoceptor beta 1	Homo sapiens	104-135	
3881933-3	1985	Thus, propranolol seems to decrease portal venous pressure by reducing portal venous flow, at least in part, as a result of reduction of cardiac output due to its beta 1 adrenergic receptor blocking action.	Propranolol	6-17	adrenoceptor beta 1	Homo sapiens	163-189	
34650198-8	2021	RESULTS: In propranolol-treated HMC-1s, the expressions of ADRB1 (beta1-AR) and ADRB2 (beta2-AR) were reduced by 70% and 60%, respectively, and that of cytokines and mediators were reduced.	Propranolol	12-23	adrenoceptor beta 1	Homo sapiens	59-64	
34650198-8	2021	RESULTS: In propranolol-treated HMC-1s, the expressions of ADRB1 (beta1-AR) and ADRB2 (beta2-AR) were reduced by 70% and 60%, respectively, and that of cytokines and mediators were reduced.	Propranolol	12-23	adrenoceptor beta 1	Homo sapiens	66-74	
34650198-10	2021	However, propranolol can work well in shRNA-ADRB1 or shRNA-ADRB2 transfected HMC-1s.	Propranolol	9-20	adrenoceptor beta 1	Homo sapiens	44-49	
34650198-14	2021	Propranolol can work well in shRNA-ADRB1 or shRNA-ADRB2 transfected HMC-1s.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	35-40	
8396157-8	1993	In Fallot patients treated with the beta-antagonist propranolol, a significant increased beta-AR number compared with untreated Fallot patients was found.	Propranolol	52-63	adrenoceptor beta 1	Homo sapiens	89-96	
34596055-0	2021	Propranolol inhibits cavernous vascular malformations by beta1 adrenergic receptor antagonism in animal models.	Propranolol	0-11	adrenoceptor beta 1	Homo sapiens	57-82	
20124-5	1977	5 Although the beta1-adrenoceptor selective blocker, metoprolol, caused decreases in baseline values for blood pressure and heart rate similar to those observed with the use of the two non-selective blockrs, it was shown in a double-blind crossover comparison with propranolol that the haemodynamic changes provoked by the mental arithmetic were not less in the presence of beta1-receptor blockade than when both beta1- and beta2-receptors were blocked.	Propranolol	265-276	adrenoceptor beta 1	Homo sapiens	15-33	
6200729-0	1984	Ethnic differences in response to beta 1-adrenoceptor blockade by propranolol.	Propranolol	66-77	adrenoceptor beta 1	Homo sapiens	34-53	
6128186-0	1982	Comparison of the beta 1 and beta 2 adrenoceptor blocking properties of acebutolol and propranolol.	Propranolol	87-98	adrenoceptor beta 1	Homo sapiens	18-48	
6128186-1	1982	The purposes of this study were to evaluate the beta 1 and beta 2 adrenoceptor blocking properties of acebutolol and propranolol and measure the plasma levels of acebutolol, its acetylated metabolite and propranolol.	Propranolol	117-128	adrenoceptor beta 1	Homo sapiens	48-78