PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16452992-0	2006	Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice.	Pindolol	32-46	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	12-18	
16452992-0	2006	Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice.	Pindolol	32-46	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	12-27	
16452992-8	2006	The selective 5-HT1A receptor antagonist, WAY-100635 (0.5 mg/kg), or (+/-)-pindolol (5 and 10 mg/kg) potentiated the effects of Prx (4 mg/kg) on cortical [5-HT]ext in 5-HT1A+/+, but not in 5-HT1A-/- mice.	Pindolol	69-83	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	167-173	
16452992-12	2006	These findings using 5-HT1A-/- mice confirm that (+/-)-pindolol behaves as an antagonist of 5-HT1A autoreceptor in mice, but its blockade of paroxetine-induced antidepressant-like effects in the FST may be due to its binding to other neurotransmitter receptors.	Pindolol	49-63	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	92-98	
9300623-7	1997	These data suggest that antagonist actions at 5-HT1A receptors (but not beta-adrenoceptors) are involved in the anxiolyticlike effects of (-)pindolol and pindobind 5-HT1A in the murine elevated plus-maze test.	Pindolol	138-149	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	46-52	
11292445-9	2001	The potentiating action of 5-HT1A, 5-HT2A/1C or 5-HT3 receptor agonist on 3alpha,5alpha-THP induced catalepsy was not blocked by prior administration of sub-effective dose (1 mg/kg, s.c.) of their respective receptor antagonists pindolol, ritanserin or ondansetron or by pretreatment with serotonergic neurotoxin 5,7-DHT (100 microg/mouse, i.c.v.).	Pindolol	229-237	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	27-33	
15777775-2	2005	We have previously demonstrated that pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) receptor antagonist, enhanced tramadol antinociception and that the selective 5-HT1A agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) reduced it.	Pindolol	37-45	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	180-186	
9566807-22	1998	The results of the present study suggest that pindolol is acting at presynaptic 5-HT1B serotonergic receptors, in addition to the 5-HT1A subtype, in augmenting the activity of antidepressants in the mouse forced swimming test.	Pindolol	46-54	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	130-136	
1359573-2	1992	In contrast, another partial 5-HT1A agonist, pindolol (10 mg/kg), slightly but significantly depressed body temperature by itself but did not attenuate hypothermia elicited by 8-OH-DPAT.	Pindolol	45-53	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	29-35	
7682614-6	1993	Spiperone, propranolol and pindolol (mixed 5-HT1A and 5-HT1B antagonists) effectively reversed both the tail-flick facilitation and the antagonistic effect on morphine sulfate-induced antinociception produced by 8-OH-DPAT and 5-CT.	Pindolol	27-35	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	43-49	
8309968-2	1993	In a resident-intruder paradigm, (-)-pindolol (1.0-20.0 mg/kg), a beta-adrenergic 5-HT1A/1B antagonist, significantly attenuated all agonistic behaviors across the dose range employed.	Pindolol	33-45	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	82-88	
32677492-2	2022	Pindolol may eliminate this inhibition when used in combination with antidepressants.Material and methods: We aimed to determine the effect of pindolol on 5-HT1A receptor response in the DRN neurons, using voltage clamp recordings and prove the potentiation of antidepressant effect of venlafaxine by pindolol through behavior experiments.	Pindolol	0-8	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	155-170	
2101330-0	1990	Inhibition of chlorpromazine-induced catalepsy by the 5-HT-1A ligands pindolol and buspirone in mice.	Pindolol	70-78	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	54-61	
32677492-0	2022	Pindolol potentiate the antidepressant effect of venlafaxine by inhibiting 5-HT1A receptor in DRN neurons of mice.	Pindolol	0-8	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	75-90	
32677492-2	2022	Pindolol may eliminate this inhibition when used in combination with antidepressants.Material and methods: We aimed to determine the effect of pindolol on 5-HT1A receptor response in the DRN neurons, using voltage clamp recordings and prove the potentiation of antidepressant effect of venlafaxine by pindolol through behavior experiments.	Pindolol	143-151	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	155-170	
32677492-2	2022	Pindolol may eliminate this inhibition when used in combination with antidepressants.Material and methods: We aimed to determine the effect of pindolol on 5-HT1A receptor response in the DRN neurons, using voltage clamp recordings and prove the potentiation of antidepressant effect of venlafaxine by pindolol through behavior experiments.	Pindolol	301-309	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	155-170	
32534819-9	2020	Pretreatment of mice with 5HT1A antagonist pindolol (10 mg/kg, i.p) or GABAA antagonist bicuculline (2 mg/kg, i.p) significantly attenuated the effect of 5-methoxyflavone in the elevated plus maze test.	Pindolol	43-51	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	26-31	
30783717-8	2019	The antidepressant-like effects of the new compounds in the FST were prevented by pretreatment of mice with pCPA (serotonin depletor), (-)pindolol (mixed 5-HT1A/1B and beta-adrenergic antagonist), and WAY 100635 (selective 5-HT1A antagonist).	Pindolol	135-146	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	154-160	
30783717-8	2019	The antidepressant-like effects of the new compounds in the FST were prevented by pretreatment of mice with pCPA (serotonin depletor), (-)pindolol (mixed 5-HT1A/1B and beta-adrenergic antagonist), and WAY 100635 (selective 5-HT1A antagonist).	Pindolol	135-146	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	223-229