PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25102452-10	2015	Minocycline administration reduced tumor-induced expression of IL-1beta in the brain, reduced depressive-like behavior, and improved grip strength without altering muscle mass.	Minocycline	0-11	interleukin 1 beta	Mus musculus	63-71	
26645224-10	2016	Minocycline-treated mice had significantly reduced hippocampal TNF-alpha and IL-1beta mRNA levels compared with LPS-treated animals.	Minocycline	0-11	interleukin 1 beta	Mus musculus	77-85	
27846628-2	2016	Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1beta (IL-1beta) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation.	Minocycline	188-199	interleukin 1 beta	Mus musculus	113-130	
27846628-2	2016	Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1beta (IL-1beta) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation.	Minocycline	188-199	interleukin 1 beta	Mus musculus	132-140	
17192486-4	2007	First, we investigated the effect of agents known to inhibit caspase-1 (minocycline and tetracycline) on IL-1beta production and retinal capillary degeneration in diabetic and galactose-fed mice.	Minocycline	72-83	interleukin 1 beta	Mus musculus	105-113	
20609517-8	2010	Ongoing hyperalgesia in GRK2(+/-) mice is reversed by minocycline administration at days 1 and 2 after IL-1beta injection.	Minocycline	54-65	interleukin 1 beta	Mus musculus	103-111	
19765544-4	2009	Minocycline repressed the expression of TNF-alpha, IL-1beta, and iNOS, decreased the apoptotic index, and inhibited poly(ADP-ribose) polymerase-1 (PARP-1) activity in the mouse small intestine.	Minocycline	0-11	interleukin 1 beta	Mus musculus	51-59	
18477398-13	2008	Furthermore, the minocycline associated recovery from LPS-induced sickness behavior was paralleled by reduced mRNA levels of Interleukin (IL)-1beta, IL-6, and indoleamine 2, 3 dioxygenase (IDO) in the cortex and hippocampus.	Minocycline	17-28	interleukin 1 beta	Mus musculus	125-147	
18477398-14	2008	Finally, in aged mice, where exaggerated neuroinflammation was elicited by LPS, minocycline pretreatment was still effective in markedly reducing mRNA levels of IL-1beta, TLR2 and IDO in the hippocampus.	Minocycline	80-91	interleukin 1 beta	Mus musculus	161-169	
17192486-7	2007	At 2 months of diabetes, minocycline inhibited hyperglycemia-induced caspase-1 activity and IL-1beta production in the retina.	Minocycline	25-36	interleukin 1 beta	Mus musculus	92-100	
11383749-5	2001	Minocycline- and saline-treated mice subjected to traumatic brain injury were compared with respect to neurological function, lesion volume, and interleukin-1beta production.	Minocycline	0-11	interleukin 1 beta	Mus musculus	145-162	
11880505-3	2002	In addition, we show that minocycline not only prevents MPTP-induced activation of microglia but also the formation of mature interleukin-1beta and the activation of NADPH-oxidase and inducible nitric oxide synthase (iNOS), three key microglial-derived cytotoxic mediators.	Minocycline	26-37	interleukin 1 beta	Mus musculus	126-143	
11383749-9	2001	Caspase-1 activity, quantified by measuring mature interleukin-1beta production by enzyme-linked immunosorbent assay, was considerably increased in mice that underwent TBI, and this increase was significantly diminished in minocycline-treated mice.	Minocycline	223-234	interleukin 1 beta	Mus musculus	51-68	
1698759-5	1990	LPS-stimulated monocytes secreted significantly more IL-1 beta in the presence of minocycline (P less than 0.01, 2-way analysis of variance).	Minocycline	82-93	interleukin 1 beta	Mus musculus	53-62	
1698759-7	1990	Loss of viability could only be associated with enhanced IL-1 beta release by monocytes with 50 mg/l minocycline.	Minocycline	101-112	interleukin 1 beta	Mus musculus	57-66	
33240677-7	2020	Minocycline reduced LPS-induced Il1b and Tnf, but not Nos2, mRNA expression.	Minocycline	0-11	interleukin 1 beta	Mus musculus	32-36	
34666120-11	2021	Minocycline also inhibited the activation of microglia/macrophages, infiltration of neutrophils, and production of inflammatory mediators, including tumor necrosis factor alpha and interleukin-1beta.	Minocycline	0-11	interleukin 1 beta	Mus musculus	181-198	
30375063-8	2018	We found up-regulation of proinflammatory cytokine genes including Il1b, Il6 and Tnfa, among which Tnfa was selectively blocked by minocycline.	Minocycline	131-142	interleukin 1 beta	Mus musculus	67-71	
30184260-10	2018	In particular, minocycline initially enhanced IL-1beta, IL-6, IL-22, GM-CSF and IL-4 colonic production and monocyte recruitment to the intestine, subsequently increasing Ly6C- MHCII+ macrophages, Tregs and type 2 intestinal immune responses.	Minocycline	15-26	interleukin 1 beta	Mus musculus	46-54	
30195729-5	2018	To that end, we inhibited the production of interleukin-1beta, one of the main inflammatory cytokines involved in the neuroinflammation triggered by amyloid peptides, in a transgenic mouse model of this disease by using minocycline, a drug known to impair the synthesis of this cytokine.	Minocycline	220-231	interleukin 1 beta	Mus musculus	44-61	
28336494-8	2017	In the hippocampus, minocycline reversed the increases in the levels of interleukin (IL-1beta), Tumor Necrosis Factor- alpha (TNF-alpha) and, IL-10 caused by Abeta (1-42).	Minocycline	20-31	interleukin 1 beta	Mus musculus	85-93