PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22675352-3	2012	We have shown that urocortin 1 and urocortin 3 are endogenously synthesized in the myocardial cells of human heart and may act on CRF type 2 receptor (CRFR2) expressed in the heart.	Urocortins	19-30	corticotropin releasing hormone receptor 2	Homo sapiens	151-156	
16054139-0	2005	Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2.	Urocortins	0-11	corticotropin releasing hormone receptor 2	Homo sapiens	60-65	
19703147-6	2009	CONCLUSION: Urocortin stimulates IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from trophoblast cells through action on CRH-R2 receptors, suggesting that this peptide may play a possible role as an anti-inflammatory agent.	Urocortins	12-21	corticotropin releasing hormone receptor 2	Homo sapiens	142-148	
17976162-4	2008	CRF(1)-preferring or non-selective agonists such as CRF, urocortin 1 (UCN1), and sauvagine stimulated cAMP production in Y79 to maximal responses of approximately 100 pmoles/10(5) cells, whereas the exclusive CRF2 receptor-selective agonists UCN2 and 3 stimulated cAMP production to maximal responses of approximately 25-30 pmoles/10(5) cells.	Urocortins	57-68	corticotropin releasing hormone receptor 2	Homo sapiens	209-213	
17170072-10	2007	Despite the substantial intracellular degradation of endocytosed urocortin in cells overexpressing either CRHR1 or CRHR2, intact urocortin could be exocytosed during the 1-h study interval.	Urocortins	65-74	corticotropin releasing hormone receptor 2	Homo sapiens	115-120	
17952632-8	2007	Urocortin induced significant Stat3 but not Stat1 activation, mediated by either CRHR1 or CRHR2.	Urocortins	0-9	corticotropin releasing hormone receptor 2	Homo sapiens	90-95	
10648719-6	2000	Unique sites of CRF-R2 expression were relatively unresponsive to CRF but were more so after icv administration of urocortin (UCN), a new mammalian CRF-related peptide.	Urocortins	115-124	corticotropin releasing hormone receptor 2	Homo sapiens	16-22	
15000874-2	2004	Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function.	Urocortins	129-138	corticotropin releasing hormone receptor 2	Homo sapiens	108-112	
7477349-6	1995	The coincidence of urotensin-like immunoreactivity with type-2 CRF receptors in brain, and our observation that urocortin is more potent than CRF at binding and activating type-2 CRF receptors, as well as at inducing c-Fos (an index of cellular activation) in regions enriched in type-2 CRF receptors, indicate that this new peptide could be an endogenous ligand for type-2 CRF receptors.	Urocortins	112-121	corticotropin releasing hormone receptor 2	Homo sapiens	172-192	
10198329-1	1999	Urocortin, a new mammalian member of the corticotropin-releasing factor (CRF) family has been proposed to be the endogenous ligand for CRF receptor 2 (CRF-R2).	Urocortins	0-9	corticotropin releasing hormone receptor 2	Homo sapiens	135-149	
10198329-1	1999	Urocortin, a new mammalian member of the corticotropin-releasing factor (CRF) family has been proposed to be the endogenous ligand for CRF receptor 2 (CRF-R2).	Urocortins	0-9	corticotropin releasing hormone receptor 2	Homo sapiens	151-157	
10417230-11	1999	Both fish neuropeptides possessed an order of magnitude less potency than human urocortin in CRF-R2 transfected cells.	Urocortins	80-89	corticotropin releasing hormone receptor 2	Homo sapiens	93-99	
7477349-6	1995	The coincidence of urotensin-like immunoreactivity with type-2 CRF receptors in brain, and our observation that urocortin is more potent than CRF at binding and activating type-2 CRF receptors, as well as at inducing c-Fos (an index of cellular activation) in regions enriched in type-2 CRF receptors, indicate that this new peptide could be an endogenous ligand for type-2 CRF receptors.	Urocortins	112-121	corticotropin releasing hormone receptor 2	Homo sapiens	172-192	
7477349-6	1995	The coincidence of urotensin-like immunoreactivity with type-2 CRF receptors in brain, and our observation that urocortin is more potent than CRF at binding and activating type-2 CRF receptors, as well as at inducing c-Fos (an index of cellular activation) in regions enriched in type-2 CRF receptors, indicate that this new peptide could be an endogenous ligand for type-2 CRF receptors.	Urocortins	112-121	corticotropin releasing hormone receptor 2	Homo sapiens	172-192	
34351805-4	2021	Urocortin-induced increase in cardiac tolerance to I/R depends mainly on the activation of corticotropin-releasing hormone receptor-2 (CRHR2) and its downstream pathways including tyrosine kinase Src, protein kinase A and C (PKA, PKCepsilon) and extracellular signal-regulated kinase (ERK1/2).	Urocortins	0-9	corticotropin releasing hormone receptor 2	Homo sapiens	91-133	
34351805-4	2021	Urocortin-induced increase in cardiac tolerance to I/R depends mainly on the activation of corticotropin-releasing hormone receptor-2 (CRHR2) and its downstream pathways including tyrosine kinase Src, protein kinase A and C (PKA, PKCepsilon) and extracellular signal-regulated kinase (ERK1/2).	Urocortins	0-9	corticotropin releasing hormone receptor 2	Homo sapiens	135-140