PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19729048-4	2009	The application of urocortin reversibly inhibited both VOCC and the frequency of DA release events via the activation of type-1 CRF receptor.	Urocortins	19-28	corticotropin releasing hormone receptor 1	Homo sapiens	121-140	
22547117-5	2013	Application of CRF and urocortin (UCN) to cerebellar slice cultures increased the density of spines on PC signaling via CRF receptors (CRF-Rs) 1 and 2 and RhoA downregulation, although the structural phenotypes of the induced spines varied, suggesting that CRF-Rs differentially induce the outgrowth of functionally distinct populations of spines.	Urocortins	23-32	corticotropin releasing hormone receptor 1	Homo sapiens	135-150	
20821057-5	2010	The protective effect of urocortin involved the activation of CRF receptor type 1, resulting in the increase of cyclic AMP (cAMP) levels.	Urocortins	25-34	corticotropin releasing hormone receptor 1	Homo sapiens	62-81	
17976162-4	2008	CRF(1)-preferring or non-selective agonists such as CRF, urocortin 1 (UCN1), and sauvagine stimulated cAMP production in Y79 to maximal responses of approximately 100 pmoles/10(5) cells, whereas the exclusive CRF2 receptor-selective agonists UCN2 and 3 stimulated cAMP production to maximal responses of approximately 25-30 pmoles/10(5) cells.	Urocortins	57-68	corticotropin releasing hormone receptor 1	Homo sapiens	0-5	
17170072-10	2007	Despite the substantial intracellular degradation of endocytosed urocortin in cells overexpressing either CRHR1 or CRHR2, intact urocortin could be exocytosed during the 1-h study interval.	Urocortins	65-74	corticotropin releasing hormone receptor 1	Homo sapiens	106-111	
15206947-4	2004	Soluble isoforms could modulate cell response with CRFR1e attenuating and CRFR1h amplifying CRFR1alpha-coupled cAMP production stimulated by urocortin.	Urocortins	141-150	corticotropin releasing hormone receptor 1	Homo sapiens	74-79	
17952632-8	2007	Urocortin induced significant Stat3 but not Stat1 activation, mediated by either CRHR1 or CRHR2.	Urocortins	0-9	corticotropin releasing hormone receptor 1	Homo sapiens	81-86	
16959871-1	2006	In most target cells, activation of the type 1 CRH receptor (CRH-R1) by CRH or urocortin (UCN I) leads to stimulation of the Gs-protein/adenylyl cyclase/protein kinase A cascade.	Urocortins	79-88	corticotropin releasing hormone receptor 1	Homo sapiens	61-67	
9423932-6	1997	Thus, for the recombinant CRF1 receptor, binding was inhibited with similar affinity by Urocortin, sauvagine, Urotensin 1 and CRF.	Urocortins	88-97	corticotropin releasing hormone receptor 1	Homo sapiens	26-30	
14657255-1	2004	Activation of CRH receptors type 1 (CRH-R1) by CRH or urocortin (UCN) leads to stimulation of multiple G proteins with consequent effects on diverse signaling cascades in a tissue-specific manner.	Urocortins	54-63	corticotropin releasing hormone receptor 1	Homo sapiens	14-34	
14657255-1	2004	Activation of CRH receptors type 1 (CRH-R1) by CRH or urocortin (UCN) leads to stimulation of multiple G proteins with consequent effects on diverse signaling cascades in a tissue-specific manner.	Urocortins	54-63	corticotropin releasing hormone receptor 1	Homo sapiens	36-42	
11784785-7	2002	Using subtype-selective CRH receptor antagonists, we provide evidence that the neuroprotective effect of exogenously added urocortin is mediated by CRHR1.	Urocortins	123-132	corticotropin releasing hormone receptor 1	Homo sapiens	148-153	
11425856-6	2001	Following thrombin cleavage, the purified protein (bNT-CRFR1) binds astressin and the agonist urocortin with high affinity.	Urocortins	94-103	corticotropin releasing hormone receptor 1	Homo sapiens	55-60	
9423932-9	1997	The pharmacological profile of specific [3H]-urocortin binding to homogentates of rat cerebellum was consistent with specific labelling of a CRF1 receptor.	Urocortins	45-54	corticotropin releasing hormone receptor 1	Homo sapiens	141-145	
7477349-5	1995	Synthetic urocortin evokes secretion of adrenocorticotropic hormone (ACTH) both in vitro and in vivo and binds and activates transfected type-1 CRF receptors, the subtype expressed by pituitary corticotropes.	Urocortins	10-19	corticotropin releasing hormone receptor 1	Homo sapiens	137-157