PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3548307-0 1987 Contribution of the renin-angiotensin-aldosterone system to development of tolerance and fluid retention in chronic congestive heart failure during prazosin treatment. Prazosin 148-156 renin Homo sapiens 20-25 9777817-10 1998 Hydrochlorothiazide and prazosin were best in low- and medium-renin profiles; captopril was best in medium- and high-renin profiles (low-, medium-, and high-renin response rates were 82%, 78%, and 14%, respectively, for hydrochlorothiazide; 88%, 67%, and 40%, respectively, for prazosin; and 51%, 83%, and 100%, respectively, for captopril for patients with baseline DBP of 95-99 mm Hg). Prazosin 24-32 renin Homo sapiens 62-67 1810694-0 1991 Prazosin"s effect in high renin hypertension complicating pheochromocytoma. Prazosin 0-8 renin Homo sapiens 26-31 1810694-1 1991 During three consecutive days of prazosin treatment in a patient with pheochromocytoma, urinary catecholamine metabolite levels were correlated with plasma renin activity. Prazosin 33-41 renin Homo sapiens 156-161 1810694-3 1991 This suggests that prazosin may interrupt the vicious cycle of worsening hypertension provoked by further activation of the renin-angiotensin system mediated by excessive circulating catecholamines. Prazosin 19-27 renin Homo sapiens 124-129 3506626-0 1987 The effect of chronic prazosin therapy on the response of the renin-angiotensin system in patients with essential hypertension. Prazosin 22-30 renin Homo sapiens 62-67 3506626-3 1987 Both before and during prazosin, tilt and frusemide each led to significant elevation of plasma active renin (P less than 0.001) and angiotensin II (P less than 0.05). Prazosin 23-31 renin Homo sapiens 103-108 3506626-5 1987 Active renin (P less than 0.05) and angiotensin II (P less than 0.01) were lower 15 hours after dosing during chronic prazosin therapy than before treatment, but changes after tilt and frusemide were not attenuated during treatment. Prazosin 118-126 renin Homo sapiens 7-12 3506626-6 1987 Chronic prazosin administration does not appear substantially to affect changes in active renin or angiotensin II in response to two standard stimuli, and may be useful in controlling hypertensive patients pending investigation of their renin-angiotensin system. Prazosin 8-16 renin Homo sapiens 237-242 3548307-2 1987 Plasma renin concentration and aldosterone level decreased slightly during prazosin therapy and norepinephrine level increased significantly. Prazosin 75-83 renin Homo sapiens 7-12 3548307-4 1987 When prazosin was added to captopril therapy, norepinephrine level increased and plasma renin concentration and aldosterone level did not change. Prazosin 5-13 renin Homo sapiens 88-93 3513808-13 1986 In chronic heart failure, vasodilatation by inhibition of the alpha adrenergic system with prazosin causes compensatory stimulation of the renin-angiotensin-aldosterone system and does not result in clinical benefit. Prazosin 91-99 renin Homo sapiens 139-144 3512121-7 1986 However, in patients with lower renin levels, prazosin decreased pulmonary capillary wedge pressure (24.8 to 21.8 mm Hg, p less than .05), decreased plasma arginine vasopressin (1.16 to 0.75 pg/ml, p less than .05), increased water excretion (62% to 85%, p less than .005), and decreased plasma epinephrine (81 to 46 pg/ml, p less than .05), while in patients with higher renin levels none of these beneficial effects were noted. Prazosin 46-54 renin Homo sapiens 32-37 3512121-7 1986 However, in patients with lower renin levels, prazosin decreased pulmonary capillary wedge pressure (24.8 to 21.8 mm Hg, p less than .05), decreased plasma arginine vasopressin (1.16 to 0.75 pg/ml, p less than .05), increased water excretion (62% to 85%, p less than .005), and decreased plasma epinephrine (81 to 46 pg/ml, p less than .05), while in patients with higher renin levels none of these beneficial effects were noted. Prazosin 46-54 renin Homo sapiens 372-377 2869077-0 1986 Role of the renin-angiotensin system in the development of hemodynamic and clinical tolerance to long-term prazosin therapy in patients with severe chronic heart failure. Prazosin 107-115 renin Homo sapiens 12-17 3881942-0 1985 Relationship of blood pressure response and the renin-angiotensin system to first-dose prazosin. Prazosin 87-95 renin Homo sapiens 48-53 3881942-2 1985 The relationship between the first-dose blood pressure and plasma renin responses to oral administration of 1 mg prazosin in 13 (seven male, six female) patients with essential hypertension (average blood pressure = 150/100 +/- 5/2 mm Hg) was studied. Prazosin 113-121 renin Homo sapiens 66-71 3881942-5 1985 This unique sensitivity of low-renin essential hypertension to prazosin may reflect an underlying increased alpha tone and/or an attendant blunted renin reactivity in this form of human essential hypertension. Prazosin 63-71 renin Homo sapiens 31-36 3881942-5 1985 This unique sensitivity of low-renin essential hypertension to prazosin may reflect an underlying increased alpha tone and/or an attendant blunted renin reactivity in this form of human essential hypertension. Prazosin 63-71 renin Homo sapiens 147-152 6378464-21 1984 We observed that prazosin did not alter heart rate and cardiac index, but suppressed the renin-angiotensin system at rest. Prazosin 17-25 renin Homo sapiens 89-94 6141721-8 1984 This unique action of prazosin may explain why it effectively lowers arterial pressure without markedly increasing cardiac output, heart rate and plasma renin activity. Prazosin 22-30 renin Homo sapiens 153-158 6175832-2 1982 We studied, in seven patients with essential hypertension, the acute effects of 0.25 mg prazosin, given intravenously, on blood pressure and plasma renin activity, the degree of alpha-blockade induced by the drug being assessed by comparing the increments in blood pressure following a test dose of phenylephrine before and after prazosin administration. Prazosin 88-96 renin Homo sapiens 148-153 6354936-1 1983 In hypertension, irrespective of its underlying etiology, the baseline pretreatment renin-sodium profile predicts the antihypertensive action or the lack of it for five major types of antihypertensive drugs: 1) diuretic agents; 2) beta-receptor blockers; 3) converting-enzyme inhibitors; 4) the alpha 1 postsynaptic blocker, prazosin; and 5) the calcium channel blockers, verapamil and nifedipine. Prazosin 325-333 renin Homo sapiens 84-89 7047170-3 1982 Twenty-two essential hypertensive men were treated with prazosin alone versus placebo, and experienced a blood pressure fall (from 114.8 +/- 3.6 down to 101.1 +/- 2.5 mmHg, p less than 0.005) unaccompanied by any change in heart rate, plasma renin activity, or several other indices of sympathetic nervous system activity (plasma dopamine-beta-hydroxylase activity; urinary excretion of free catecholamines and vanillyl mandelic acid; all p less than 0.1). Prazosin 56-64 renin Homo sapiens 242-247 6274574-4 1981 Twenty minutes after the infusion of prazosin, when the pressor response to phenylephrine was reduced by 80% with respect to control, (i) mean arterial pressure was practically unchanged, (ii) plasma renin activity was almost doubled and (iii) the increases in plasma renin activity in response to isoprenaline were significantly greater, both in absolute and percentage values, than those observed before prazosin. Prazosin 37-45 renin Homo sapiens 200-205 6274574-4 1981 Twenty minutes after the infusion of prazosin, when the pressor response to phenylephrine was reduced by 80% with respect to control, (i) mean arterial pressure was practically unchanged, (ii) plasma renin activity was almost doubled and (iii) the increases in plasma renin activity in response to isoprenaline were significantly greater, both in absolute and percentage values, than those observed before prazosin. Prazosin 37-45 renin Homo sapiens 268-273 6274574-6 1981 The increments in baseline plasma renin activity induced by prazosin in the absence of decrease in arterial pressure and the enhancement in renin responsiveness to the beta-adrenoceptor stimulus suggest that, in man, the juxtaglomerular alpha 1-adrenoceptors exert a direct, suppressive action on renin release. Prazosin 60-68 renin Homo sapiens 34-39 7309905-0 1981 Effects of chronic prazosin treatment on the renin-angiotensin-aldosterone system in man. Prazosin 19-27 renin Homo sapiens 45-50 7032827-0 1981 The effect of oral prazosin on blood pressure and plasma concentrations of renin and angiotensin II in man. Prazosin 19-27 renin Homo sapiens 75-99 7032827-6 1981 After an initial dose of prazosin (2 mg) there was a significant fall in recumbent blood pressure with progressive increases in plasma active renin and angiotensin II concentrations. Prazosin 25-33 renin Homo sapiens 142-166 7032827-12 1981 Prazosin therefore stimulates the renin--angiotensin system acutely, both after the initial dose and during long-term therapy; however, no effect on renin and angiotensin II is apparent 15 h after the last dose of prazosin. Prazosin 0-8 renin Homo sapiens 34-39 6175832-4 1982 Prazosin infusion caused, within 20 min, a marked reduction of the pressor response to phenylephrine, a significant increment in plasma renin activity, and no change in blood pressure. Prazosin 0-8 renin Homo sapiens 136-141 6175832-5 1982 The increments in renin in response to isoproterenol were significantly greater, both in absolute and percent values, after rather than before prazosin. Prazosin 143-151 renin Homo sapiens 18-23 6175837-9 1982 This reflects an important role of alpha-adrenoceptor-mediated vascular regulation in patients with heart failure in whom long-term treatment with prazosin produces a sustained and well-tolerated vasodilator effect without further rise in catecholamines and renin. Prazosin 147-155 renin Homo sapiens 258-263 7023672-0 1981 Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension. Prazosin 10-18 renin Homo sapiens 44-49 7374-4 1976 Standing pulse rate and body weight were higher and plasma renin activity lower during prazosin treatment. Prazosin 87-95 renin Homo sapiens 59-64 7397054-5 1980 3 Indomethacin prevented the rise in plasma renin activity seen following administration of prazosin alone. Prazosin 92-100 renin Homo sapiens 44-49 282080-2 1978 The effects of oral administration of 4.5 mg of prazosin/day on blood pressure and on plasma renin activity were assessed in patients with essential hypertension and in healthy normotensive volunteer subjects. Prazosin 48-56 renin Homo sapiens 93-98 282080-9 1978 The results indicate the prazosin exerts its hypotensive action and suppresses plasma renin activity particularly in patients with high renin-essential hypertension. Prazosin 25-33 renin Homo sapiens 86-91 282080-9 1978 The results indicate the prazosin exerts its hypotensive action and suppresses plasma renin activity particularly in patients with high renin-essential hypertension. Prazosin 25-33 renin Homo sapiens 136-141 370766-8 1978 Prazosine induces only a slight increase plasma renin activity. Prazosin 0-9 renin Homo sapiens 48-53 916931-0 1977 Prazosin in severe in hypertension effect on blood pressure, plasma renin activity and in hypertensive emergencies. Prazosin 0-8 renin Homo sapiens 68-73 7007686-11 1980 While, further investigation is necessary to define the effect of prazosin on plasma renin activity. Prazosin 66-74 renin Homo sapiens 85-90 228024-5 1979 Plasma renin activity and heart rate increased during hypoglycemia; the increases were greater in patients taking prazosin or hydralazine. Prazosin 114-122 renin Homo sapiens 7-12 479380-0 1979 Effects of prazosin on plasma renin activity and blood pressure. Prazosin 11-19 renin Homo sapiens 30-35 282080-0 1978 Effect of prazosin on blood pressure and plasma renin activity in man. Prazosin 10-18 renin Homo sapiens 48-53 933955-7 1976 Plasma renin activity was reduced to 25% of the control value in a group treated with prazosin alone. Prazosin 86-94 renin Homo sapiens 7-12