PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30573525-5 2019 Importantly, genetic inactivation of genes that raise the mitochondrial saccharopine precursors lysine and alpha-ketoglutarate strongly suppresses SDH mutation-induced saccharopine accumulation and mitochondrial abnormalities in C. elegans Thus, adequate saccharopine catabolism is essential for mitochondrial homeostasis. Ketoglutaric Acids 107-126 aminoadipate-semialdehyde synthase Mus musculus 147-150 28928232-7 2017 The stem-like characteristics are reversed by alpha-ketoglutarate, suggesting that SDH-associated tumorigenesis results from dedifferentiation driven by an imbalance in cellular metabolites of the TCA cycle. Ketoglutaric Acids 46-65 aminoadipate-semialdehyde synthase Mus musculus 83-86