PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24945799-7 2014 Vvl and Kni bind to PG specific cis-regulatory elements that are required for expression of the ecdysone biosynthetic genes. Ecdysone 96-104 ventral veins lacking Drosophila melanogaster 0-3 24945799-8 2014 Knock down of either vvl or kni in the PG results in a larval developmental arrest due to failure in ecdysone production. Ecdysone 101-109 ventral veins lacking Drosophila melanogaster 21-24 24945799-9 2014 Furthermore, Vvl and Kni are also required for maintenance of TOR/S6K and prothoracicotropic hormone (PTTH) signaling in the PG, two major pathways that control ecdysone biosynthesis and PG cell growth. Ecdysone 161-169 ventral veins lacking Drosophila melanogaster 13-16 24945799-11 2014 Our data show that Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting PTTH and TOR/S6K signaling. Ecdysone 49-57 ventral veins lacking Drosophila melanogaster 19-22