PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29567866-0	2018	Kruppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.	Ecdysone	35-43	Kruppel homolog 1	Drosophila melanogaster	0-17	
29567866-3	2018	Here, we demonstrate that the expression of the Kruppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes.	Ecdysone	145-153	Kruppel homolog 1	Drosophila melanogaster	67-72	
29567866-3	2018	Here, we demonstrate that the expression of the Kruppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes.	Ecdysone	145-153	Kruppel homolog 1	Drosophila melanogaster	413-418	
29567866-7	2018	Taken together, our data indicate direct and conserved Kr-h1 repression of insect ecdysone biosynthesis in response to JH stimulation, providing insights into mechanisms underlying the antagonistic roles of JH and ecdysone.	Ecdysone	82-90	Kruppel homolog 1	Drosophila melanogaster	55-60	
29567866-3	2018	Here, we demonstrate that the expression of the Kruppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes.	Ecdysone	145-153	Kruppel homolog 1	Drosophila melanogaster	48-65	
17562531-12	2007	Thus, although KR-H1 has a potential for modulating neuronal morphogenesis, it appears physiologically involved in coordinating general ecdysone signaling.	Ecdysone	136-144	Kruppel homolog 1	Drosophila melanogaster	15-20	
15661647-2	2005	The Kr-h gene of Drosophila is a modulator of both the embryonic and metamorphic hierarchies of ecdysone responsive genes, but its mode of action is puzzling as mutants have both quantitative and qualitative (timing) effects on the ecdysone responses.	Ecdysone	96-104	Kruppel homolog 1	Drosophila melanogaster	4-8	
15661647-2	2005	The Kr-h gene of Drosophila is a modulator of both the embryonic and metamorphic hierarchies of ecdysone responsive genes, but its mode of action is puzzling as mutants have both quantitative and qualitative (timing) effects on the ecdysone responses.	Ecdysone	232-240	Kruppel homolog 1	Drosophila melanogaster	4-8