PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23347515-6 2013 PTTH stimulates ecdysone production through a Ras/Raf/ERK signaling cascade; however, comparatively little is known about the downstream targets of this pathway. Ecdysone 16-24 Prothoracicotropic hormone Drosophila melanogaster 0-4 21980261-2 2011 The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic hormone). Ecdysone 29-37 Prothoracicotropic hormone Drosophila melanogaster 82-86 21980261-2 2011 The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic hormone). Ecdysone 29-37 Prothoracicotropic hormone Drosophila melanogaster 88-113 34552169-5 2021 In Drosophila melanogaster different signals have been shown to regulate the production of ecdysone, such as PTTH/Torso, TGFss and Egfr signaling. Ecdysone 91-99 Prothoracicotropic hormone Drosophila melanogaster 109-113 18061567-2 2007 Prothoracicotropic hormone (PTTH) has been proposed to play an essential role in regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and metamorphosis. Ecdysone 125-133 Prothoracicotropic hormone Drosophila melanogaster 0-26 18061567-2 2007 Prothoracicotropic hormone (PTTH) has been proposed to play an essential role in regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and metamorphosis. Ecdysone 125-133 Prothoracicotropic hormone Drosophila melanogaster 28-32 34975366-2 2021 In Drosophila melanogaster, prothoracicotropic hormone (PTTH)-releasing neurons are considered to be the primary promoting factor in ecdysone biosynthesis. Ecdysone 133-141 Prothoracicotropic hormone Drosophila melanogaster 56-60 32220314-5 2020 It is widely accepted that ecdysone biosynthesis in Drosophila is mainly induced by the activation of tyrosine kinase (RTK) Torso by the prothoracicotropic hormone (Ptth) produced into two pairs of neurosecretory cells that project their axons onto the PG [7, 8]. Ecdysone 27-35 Prothoracicotropic hormone Drosophila melanogaster 165-169 32631830-7 2020 Our findings indicate the existence of a feedback circuit in which rising ecdysone levels trigger, via EcR activity in the PTTHn, the PTTH surge that generates the maturation-inducing ecdysone peak toward the end of larval development. Ecdysone 74-82 Prothoracicotropic hormone Drosophila melanogaster 123-127 32631830-7 2020 Our findings indicate the existence of a feedback circuit in which rising ecdysone levels trigger, via EcR activity in the PTTHn, the PTTH surge that generates the maturation-inducing ecdysone peak toward the end of larval development. Ecdysone 184-192 Prothoracicotropic hormone Drosophila melanogaster 123-127 32196731-6 2020 In addition, miR-8-3p was expressed in the prothoracic gland (PG), which produces and releases ecdysone in response to prothoracicotropic hormone (PTTH). Ecdysone 95-103 Prothoracicotropic hormone Drosophila melanogaster 147-151 29467242-3 2018 The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Ecdysone 160-168 Prothoracicotropic hormone Drosophila melanogaster 17-43 31415125-3 2019 RESULTS: Overexpression of activated Ras in developing eye/wing discs inhibited Ptth expression in brain via upregulated JNK signaling mediated Dilp8 secretion from imaginal discs, which inhibited ecdysone synthesis in prothoracic gland after pupariation, leading to death of ~25- to 30-hour-old pupae. Ecdysone 197-205 Prothoracicotropic hormone Drosophila melanogaster 80-84 29467242-3 2018 The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Ecdysone 160-168 Prothoracicotropic hormone Drosophila melanogaster 45-49 25605909-2 2015 Ecdysone production is regulated in the prothoracic gland (PG) by prothoracicotropic hormone (PTTH) and insulin-like peptides (Ilps). Ecdysone 0-8 Prothoracicotropic hormone Drosophila melanogaster 94-98 26441350-6 2015 These neurons are located in the pars intercerebralis, an important neuroendocrine area in the brain, and make physical contacts with the PTTH neurons that ultimately control the production and release of the molting steroid ecdysone. Ecdysone 225-233 Prothoracicotropic hormone Drosophila melanogaster 138-142 25605909-7 2015 Thus, monoaminergic autocrine signaling in the PG regulates ecdysone biogenesis in a coordinated fashion on activation by PTTH and Ilps. Ecdysone 60-68 Prothoracicotropic hormone Drosophila melanogaster 122-126 24945799-9 2014 Furthermore, Vvl and Kni are also required for maintenance of TOR/S6K and prothoracicotropic hormone (PTTH) signaling in the PG, two major pathways that control ecdysone biosynthesis and PG cell growth. Ecdysone 161-169 Prothoracicotropic hormone Drosophila melanogaster 102-106 24945799-11 2014 Our data show that Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting PTTH and TOR/S6K signaling. Ecdysone 49-57 Prothoracicotropic hormone Drosophila melanogaster 158-162