PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10419696-10	1999	These studies demonstrate that DHR3 is an essential regulator of the betaFTZ-F1 midprepupal competence factor, providing a functional link between the late larval and prepupal responses to ecdysone.	Ecdysone	189-197	Hormone receptor 3	Drosophila melanogaster	31-35	
25747870-5	2015	As observed in Drosophila, NO signaling targets the nuclear hormone receptor beta fushi tarazu transcription factor 1 (betaFTZ-F1) through activation of Drosophila hormone receptor 3 (DHR3), two key regulators of ecdysone production and metamorphic tissue progression.	Ecdysone	213-221	Hormone receptor 3	Drosophila melanogaster	164-182	
25747870-5	2015	As observed in Drosophila, NO signaling targets the nuclear hormone receptor beta fushi tarazu transcription factor 1 (betaFTZ-F1) through activation of Drosophila hormone receptor 3 (DHR3), two key regulators of ecdysone production and metamorphic tissue progression.	Ecdysone	213-221	Hormone receptor 3	Drosophila melanogaster	184-188	
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysone	22-30	Hormone receptor 3	Drosophila melanogaster	145-149	
11335116-2	2001	Studies of the ecdysone response in Drosophila and other insects have shown that 20E exerts its effects initially by the induction of a small number of early genes, including the orphan nuclear receptors HR3, that transduce and amplify the hormone signal.	Ecdysone	15-23	Hormone receptor 3	Drosophila melanogaster	204-207	
10419696-11	1999	Induction of DHR3 in early prepupae ensures that responses to the prepupal ecdysone pulse will be distinct from responses to the late larval pulse and thus that the animal progresses in an appropriate manner through the early stages of metamorphosis.	Ecdysone	75-83	Hormone receptor 3	Drosophila melanogaster	13-17	
9165123-4	1997	DHR3 protein is bound to many ecdysone-induced puffs in the polytene chromosomes, including the early puffs that encode the BR-C and E74 regulatory genes, as well as the E75, E78 and betaFTZ-F1 orphan receptor loci.	Ecdysone	30-38	Hormone receptor 3	Drosophila melanogaster	0-4	
9165123-8	1997	DHR3 thus appears to function as a switch that defines the larval-prepupal transition by arresting the early regulatory response to ecdysone at puparium formation and facilitating the induction of the betaFTZ-F1 competence factor in mid-prepupae.	Ecdysone	132-140	Hormone receptor 3	Drosophila melanogaster	0-4	
9342356-0	1997	DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis.	Ecdysone	9-17	Hormone receptor 3	Drosophila melanogaster	0-4	
9342356-2	1997	The DHR3 gene, located within the 46F early-late ecdysone-inducible chromosome puff, encodes an orphan nuclear receptor that recently has been shown to exert both positive and negative regulatory effects in the ecdysone-induced genetic hierarchies at metamorphosis.	Ecdysone	49-57	Hormone receptor 3	Drosophila melanogaster	4-8	
9342356-2	1997	The DHR3 gene, located within the 46F early-late ecdysone-inducible chromosome puff, encodes an orphan nuclear receptor that recently has been shown to exert both positive and negative regulatory effects in the ecdysone-induced genetic hierarchies at metamorphosis.	Ecdysone	211-219	Hormone receptor 3	Drosophila melanogaster	4-8	
9082981-1	1997	The functions of the ecdysone-induced DHR3 and E75B orphan nuclear receptors in the early stages of Drosophila metamorphosis were investigated.	Ecdysone	21-29	Hormone receptor 3	Drosophila melanogaster	38-42