PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11908877-3 2001 To determine the roles of p16 alterations in glioma formation, we have established ecdysone-driven inducible p16 expression in the human glioblastoma cell line CL-4, which were derived from p16-null U87MG cells. Ecdysone 83-91 cyclin dependent kinase inhibitor 2A Homo sapiens 109-112 11593424-2 2001 To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb). Ecdysone 196-204 cyclin dependent kinase inhibitor 2A Homo sapiens 229-232 11593424-2 2001 To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb). Ecdysone 196-204 cyclin dependent kinase inhibitor 2A Homo sapiens 233-238 11908877-3 2001 To determine the roles of p16 alterations in glioma formation, we have established ecdysone-driven inducible p16 expression in the human glioblastoma cell line CL-4, which were derived from p16-null U87MG cells. Ecdysone 83-91 cyclin dependent kinase inhibitor 2A Homo sapiens 109-112