PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28627423-6	2017	In PTTH knockout larvae, peak levels of ecdysone titers in the hemolymph were dramatically reduced and the timing of peaks was delayed, suggesting that protracted larval development is a result of the reduced and delayed synthesis of ecdysone in the PG.	Ecdysone	40-48	prothoracicotropic hormone	Bombyx mori	3-7	
28627423-6	2017	In PTTH knockout larvae, peak levels of ecdysone titers in the hemolymph were dramatically reduced and the timing of peaks was delayed, suggesting that protracted larval development is a result of the reduced and delayed synthesis of ecdysone in the PG.	Ecdysone	234-242	prothoracicotropic hormone	Bombyx mori	3-7	
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	43-51	prothoracicotropic hormone	Bombyx mori	71-75	
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133	
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133	
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133	
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133	
28627423-8	2017	We also found that mRNA levels of genes involved in ecdysone biosynthesis and ecdysteroid signaling pathways were significantly reduced in PTTH knockouts.	Ecdysone	52-60	prothoracicotropic hormone	Bombyx mori	139-143	
7981038-2	1994	PTTH stimulates the prothoracic glands to synthesize and release ecdysone, and is therefore a key hormone for the regulation of insect moulting and metamorphosis.	Ecdysone	65-73	prothoracicotropic hormone	Bombyx mori	0-4	
26698662-1	2015	In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone.	Ecdysone	160-168	prothoracicotropic hormone	Bombyx mori	54-58	
22559968-1	2012	The insect brain secretes prothoracicotropic hormone (PTTH), which stimulates the prothoracic gland to synthesize ecdysone.	Ecdysone	114-122	prothoracicotropic hormone	Bombyx mori	54-58	
16045756-1	2005	Prothoracicotropic hormone (PTTH) plays a central role in controlling molting, metamorphosis, and diapause termination in insects by stimulating the prothoracic glands to synthesize and release the molting hormone, ecdysone.	Ecdysone	215-223	prothoracicotropic hormone	Bombyx mori	0-26	
16045756-1	2005	Prothoracicotropic hormone (PTTH) plays a central role in controlling molting, metamorphosis, and diapause termination in insects by stimulating the prothoracic glands to synthesize and release the molting hormone, ecdysone.	Ecdysone	215-223	prothoracicotropic hormone	Bombyx mori	28-32	
2315701-1	1990	Prothoracicotropic hormone (PTTH), a brain secretory polypeptide of insects, stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.	Ecdysone	134-142	prothoracicotropic hormone	Bombyx mori	0-26	
2315701-1	1990	Prothoracicotropic hormone (PTTH), a brain secretory polypeptide of insects, stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.	Ecdysone	134-142	prothoracicotropic hormone	Bombyx mori	28-32	
6714648-5	1984	Five picograms of PTTH directly stimulated the prothoracic glands in vitro so as to enhance ecdysone release.	Ecdysone	92-100	prothoracicotropic hormone	Bombyx mori	18-22