PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8185658-3 1994 However, membrane-bound PK-C activity in the sensitive HL-60 cells was approximately 3-fold increased in the presence of ET-18-OCH3, whereas in differentiated HL-60 cells and K562 cells PK-C was not influenced by ET-18-OCH3. edelfosine 121-131 proline rich transmembrane protein 2 Homo sapiens 24-28 7585518-1 1995 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC). edelfosine 0-53 proline rich transmembrane protein 2 Homo sapiens 183-199 7585518-1 1995 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC). edelfosine 0-53 proline rich transmembrane protein 2 Homo sapiens 201-204 7585518-1 1995 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC). edelfosine 55-65 proline rich transmembrane protein 2 Homo sapiens 183-199 7585518-1 1995 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC). edelfosine 55-65 proline rich transmembrane protein 2 Homo sapiens 201-204 7585518-2 1995 Our previous studies indicate that the selective inhibition of tumor cell growth by ET-18-OCH3 may be due to altered signal transduction mechanisms, including the inhibition of PKC. edelfosine 84-94 proline rich transmembrane protein 2 Homo sapiens 177-180 7585518-3 1995 To further define the mechanism of action of ET-18-OCH3, we have used it to study the role of PKC in regulation of the transcription factor NF-kappa B, which is activated by diverse stimuli. edelfosine 45-55 proline rich transmembrane protein 2 Homo sapiens 94-97 8185658-7 1994 Moreover, cells depleted of PK-C activity showed similar sensitivity or resistance to ET-18-OCH3 as cells expressing PK-C activity. edelfosine 86-96 proline rich transmembrane protein 2 Homo sapiens 28-32 8185658-8 1994 These results suggest that a role of PK-C in the cytotoxic action of ET-18-OCH3 is very unlikely. edelfosine 69-79 proline rich transmembrane protein 2 Homo sapiens 37-41 2308148-6 1990 The biological testing of these analogues on PKC stimulated with rac-1-O-oleoyl-2-O-acetylglycerol showed several analogues with inhibition comparable to that of Et-18-OMe. edelfosine 162-171 proline rich transmembrane protein 2 Homo sapiens 45-48