PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25465296-11	2015	Edelfosine also displaced survival PI3K/Akt signaling from lipid rafts, leading to Akt inhibition, in mantle cell lymphoma cells.	edelfosine	0-10	AKT serine/threonine kinase 1	Homo sapiens	40-43	
26944919-4	2016	Edelfosine caused a dose-dependent decrease in AKT activity, but did not affect the expression of total AKT in either cell line.	edelfosine	0-10	AKT serine/threonine kinase 1	Homo sapiens	47-50	
25465296-11	2015	Edelfosine also displaced survival PI3K/Akt signaling from lipid rafts, leading to Akt inhibition, in mantle cell lymphoma cells.	edelfosine	0-10	AKT serine/threonine kinase 1	Homo sapiens	83-86	
24413065-6	2014	In all three cell lines [Gem+Clo+Ed] decreased the level of phosphorylation of the pro-survival protein AKT and activated the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) stress signaling pathway, which in J45.01 cells resulted in the phosphorylation and heterodimerization of the transcription factors ATF2 and c-Jun.	edelfosine	33-35	AKT serine/threonine kinase 1	Homo sapiens	104-107	
23415083-4	2013	Among the synthesized compounds, 5a, 5b and 6c exhibited potent inhibitory Akt phosphorylation effects with IC50 value of 3.1, 2.0 and 3.0 muM, respectively, and their potencies were better than those of three reference compounds miltefosine, perifosine and edelfosine.	edelfosine	258-268	AKT serine/threonine kinase 1	Homo sapiens	75-78	
17891170-3	2008	Edelfosine treatment recruited Hsp90, c-Jun N-terminal kinase (JNK) and apoptotic molecules in lipid rafts, but not the JNK regulators apoptosis signal-regulating kinase 1 (ASK1) and Daxx, or the survival signaling molecules extracellular signal-regulated kinase (ERK) and Akt.	edelfosine	0-10	AKT serine/threonine kinase 1	Homo sapiens	273-276	
18296338-5	2008	ET-18-O-CH3 also inhibited constitutive activation of ERK1/2, p38 MAPK, and Akt/protein kinase B, which was blunted by a selective COX-2 inhibitor SC58635.	edelfosine	0-11	AKT serine/threonine kinase 1	Homo sapiens	76-79	
18296338-7	2008	Based on these findings, it is likely that ET-18-O-CH3 inactivates ERK1/2, Akt, and NF-kappaB signaling via COX-2 induction in MCF10A-ras cells, thereby inducing apoptosis of these cells.	edelfosine	43-54	AKT serine/threonine kinase 1	Homo sapiens	75-78