PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25593994-6	2014	The RIPK1-dependent necroptosis inhibitors necrostatin-1 (Nec-1) and Nec-1s as well as siRNA-mediated silencing of RIPK3 inhibited edelfosine-induced necroptosis, resulting in increased caspase-dependent apoptosis in edelfosine-treated glioblastoma U118 cells.	edelfosine	217-227	receptor interacting serine/threonine kinase 1	Homo sapiens	4-9	
25593994-6	2014	The RIPK1-dependent necroptosis inhibitors necrostatin-1 (Nec-1) and Nec-1s as well as siRNA-mediated silencing of RIPK3 inhibited edelfosine-induced necroptosis, resulting in increased caspase-dependent apoptosis in edelfosine-treated glioblastoma U118 cells.	edelfosine	131-141	receptor interacting serine/threonine kinase 1	Homo sapiens	4-9	
25749008-4	2015	Combined treatment of U0126 and edelfosine totally inhibited ERK1/2 phosphorylation, and led to RIPK1 and RelA/NF-kappaB degradation, together with a strong activation of caspase-3 and -8.	edelfosine	32-42	receptor interacting serine/threonine kinase 1	Homo sapiens	96-101	
25593994-8	2014	These data support a major role for RIPK1 and RIPK3 in the induction of necrotic cell death and in the switch from necrosis to apoptosis following edelfosine treatment.	edelfosine	147-157	receptor interacting serine/threonine kinase 1	Homo sapiens	36-41