PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12851688-3	2003	The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP).	edelfosine	110-120	mitogen-activated protein kinase 1	Homo sapiens	261-264	
12851688-3	2003	The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP).	edelfosine	41-51	mitogen-activated protein kinase 1	Homo sapiens	255-258	
12851688-9	2003	These results demonstrate that edelfosine-induced changes in JNK, ERK, p38, or PARP are not good predictors of cell susceptibility to edelfosine-induced cytotoxicity.	edelfosine	31-41	mitogen-activated protein kinase 1	Homo sapiens	66-69	
12851688-3	2003	The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP).	edelfosine	41-51	mitogen-activated protein kinase 1	Homo sapiens	261-264	
12851688-3	2003	The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP).	edelfosine	110-120	mitogen-activated protein kinase 1	Homo sapiens	255-258	
18296338-0	2008	The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.	edelfosine	26-36	mitogen-activated protein kinase 1	Homo sapiens	144-147	
17891170-3	2008	Edelfosine treatment recruited Hsp90, c-Jun N-terminal kinase (JNK) and apoptotic molecules in lipid rafts, but not the JNK regulators apoptosis signal-regulating kinase 1 (ASK1) and Daxx, or the survival signaling molecules extracellular signal-regulated kinase (ERK) and Akt.	edelfosine	0-10	mitogen-activated protein kinase 1	Homo sapiens	225-262	
17891170-3	2008	Edelfosine treatment recruited Hsp90, c-Jun N-terminal kinase (JNK) and apoptotic molecules in lipid rafts, but not the JNK regulators apoptosis signal-regulating kinase 1 (ASK1) and Daxx, or the survival signaling molecules extracellular signal-regulated kinase (ERK) and Akt.	edelfosine	0-10	mitogen-activated protein kinase 1	Homo sapiens	264-267	
25749008-6	2015	Inhibition of ERK phosphorylation also led to a dramatic increase in edelfosine-induced apoptosis when the alkylphospholipid analog was used at a low micromolar range, suggesting that ERK phosphorylation acts as a potent regulator of apoptotic cell death in edelfosine-treated U118 cells.	edelfosine	69-79	mitogen-activated protein kinase 1	Homo sapiens	14-17	
25749008-6	2015	Inhibition of ERK phosphorylation also led to a dramatic increase in edelfosine-induced apoptosis when the alkylphospholipid analog was used at a low micromolar range, suggesting that ERK phosphorylation acts as a potent regulator of apoptotic cell death in edelfosine-treated U118 cells.	edelfosine	69-79	mitogen-activated protein kinase 1	Homo sapiens	184-187	
25749008-6	2015	Inhibition of ERK phosphorylation also led to a dramatic increase in edelfosine-induced apoptosis when the alkylphospholipid analog was used at a low micromolar range, suggesting that ERK phosphorylation acts as a potent regulator of apoptotic cell death in edelfosine-treated U118 cells.	edelfosine	258-268	mitogen-activated protein kinase 1	Homo sapiens	14-17	
25749008-6	2015	Inhibition of ERK phosphorylation also led to a dramatic increase in edelfosine-induced apoptosis when the alkylphospholipid analog was used at a low micromolar range, suggesting that ERK phosphorylation acts as a potent regulator of apoptotic cell death in edelfosine-treated U118 cells.	edelfosine	258-268	mitogen-activated protein kinase 1	Homo sapiens	184-187	
18296338-0	2008	The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.	edelfosine	38-49	mitogen-activated protein kinase 1	Homo sapiens	144-147	
18296338-5	2008	ET-18-O-CH3 also inhibited constitutive activation of ERK1/2, p38 MAPK, and Akt/protein kinase B, which was blunted by a selective COX-2 inhibitor SC58635.	edelfosine	0-11	mitogen-activated protein kinase 1	Homo sapiens	62-65