PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12894505-0	2003	The antitumor ether lipid 1-Q-octadecyl-2-O-methyl-rac-glycerophosphocholine (ET-18-OCH3) inhibits the association between Ras and Raf-1.	edelfosine	78-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	131-136	
12894505-4	2003	Since ET-18-OCH3 did not inhibit the activities of the kinases in the cascade, the reduced Raf-1 levels appeared to be the cause for the reduction in the magnitude and duration of MAPK activity.	edelfosine	6-16	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	91-96	
12894505-12	2003	CONCLUSION: Our findings suggest that ET-18-OCH3 associates specifically with Raf-1 in the cytosol and interferes in the interaction of Raf-1 with activated Ras, thereby reducing the levels that are translocated to the membrane for activation.	edelfosine	38-48	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	78-83	
12894505-12	2003	CONCLUSION: Our findings suggest that ET-18-OCH3 associates specifically with Raf-1 in the cytosol and interferes in the interaction of Raf-1 with activated Ras, thereby reducing the levels that are translocated to the membrane for activation.	edelfosine	38-48	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	136-141	
12894505-13	2003	Thus Raf-1 appears to be a molecular target of ET-18-OCH3.	edelfosine	47-57	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	5-10	
10519389-0	1999	Decreased sensitivity to 1-O-octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 cells adapted for serum-free growth correlates with constitutive association of Raf-1 with cellular membranes.	edelfosine	25-71	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	161-166	
10519389-1	1999	We have previously shown that inhibition of MCF-7 cell proliferation by 1-O-octadecyl-2-O-methyl-glycerophosphocholine (ET-18-OCH3) is linked to a drug-induced decrease in membrane Raf-1 levels and the subsequent inhibition of mitogen-activated protein (MAP) kinase activation in response to growth factor stimulation.	edelfosine	72-118	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	181-186	
10519389-6	1999	In both cell types, incubation with ET-18-OCH3 had no effect on the membrane-Raf-1 levels, suggesting that ET-18-OCH3-induced reduction of Raf-1 levels in growth factor-stimulated MCF-7 cells is due to inhibition of Raf translocation.	edelfosine	107-117	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	139-144	
8770865-6	1996	However, an interference in the association of Raf-1 with membranes and a resultant decrease in Raf-1 kinase activity in membranes of ET18-OCH3-treated cells was observed.	edelfosine	134-143	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	47-52	
8770865-6	1996	However, an interference in the association of Raf-1 with membranes and a resultant decrease in Raf-1 kinase activity in membranes of ET18-OCH3-treated cells was observed.	edelfosine	134-143	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	96-101	
8770865-9	1996	These results suggest that inhibition of the MAPK cascade by ET18-OCH3 as a result of its effect on Raf-1 activation may be an important mechanism by which ET18-OCH3 inhibits cell proliferation.	edelfosine	61-70	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	100-105	
8770865-9	1996	These results suggest that inhibition of the MAPK cascade by ET18-OCH3 as a result of its effect on Raf-1 activation may be an important mechanism by which ET18-OCH3 inhibits cell proliferation.	edelfosine	156-165	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	100-105