PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16253239-7	2005	Based on these findings, it is likely that ET-18-O-CH3 induces COX-2 expression and production of 15d-PGJ2 which may mediate the ET-18-O-CH3-induced apoptosis in MCF10A-ras cells.	edelfosine	43-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68	
16253239-0	2005	ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells.	edelfosine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57	
18296338-2	2008	ET-18-O-CH3 treatment also enhanced the production of prostaglandin E2 (PGE2), a major COX-2 product.	edelfosine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92	
18296338-5	2008	ET-18-O-CH3 also inhibited constitutive activation of ERK1/2, p38 MAPK, and Akt/protein kinase B, which was blunted by a selective COX-2 inhibitor SC58635.	edelfosine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136	
18296338-7	2008	Based on these findings, it is likely that ET-18-O-CH3 inactivates ERK1/2, Akt, and NF-kappaB signaling via COX-2 induction in MCF10A-ras cells, thereby inducing apoptosis of these cells.	edelfosine	43-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	108-113	
16253239-2	2005	Contrary to this notion, we have found that a novel alkylphospholipid type antitumor agent ET-18-O-CH3 (1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine) induces COX-2 expression in H-ras transformed human breast epithelial cells (MCF10A-ras) while it causes apoptosis at the same concentration range.	edelfosine	91-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	163-168	
16253239-4	2005	ET-18-O-CH3 enhanced the transcriptional activities of cyclic AMP response element which is a key regulator of COX-2 expression.	edelfosine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116