PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17891170-0 2008 Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. edelfosine 93-103 mitogen-activated protein kinase 8 Homo sapiens 51-74 17891170-4 2008 Following edelfosine treatment, Hsp90 bound to JNK in lipid rafts and Hsp90-JNK clusters were identified at the plasma membrane by immunoelectron microscopy. edelfosine 10-20 mitogen-activated protein kinase 8 Homo sapiens 47-50 17891170-4 2008 Following edelfosine treatment, Hsp90 bound to JNK in lipid rafts and Hsp90-JNK clusters were identified at the plasma membrane by immunoelectron microscopy. edelfosine 10-20 mitogen-activated protein kinase 8 Homo sapiens 76-79 17891170-5 2008 Hsp90 inhibition reduced JNK protein level in lipid rafts and turned proapoptotic persistent JNK activation into a transient response in edelfosine-treated cells. edelfosine 137-147 mitogen-activated protein kinase 8 Homo sapiens 25-28 17891170-5 2008 Hsp90 inhibition reduced JNK protein level in lipid rafts and turned proapoptotic persistent JNK activation into a transient response in edelfosine-treated cells. edelfosine 137-147 mitogen-activated protein kinase 8 Homo sapiens 93-96 17891170-6 2008 Decrease in edelfosine-induced JNK activation and apoptosis by Hsp90 inhibition was prevented through proteasome inhibition, suggesting that Hsp90 inhibition diminishes apoptosis by promoting JNK protein degradation. edelfosine 12-22 mitogen-activated protein kinase 8 Homo sapiens 31-34 17891170-6 2008 Decrease in edelfosine-induced JNK activation and apoptosis by Hsp90 inhibition was prevented through proteasome inhibition, suggesting that Hsp90 inhibition diminishes apoptosis by promoting JNK protein degradation. edelfosine 12-22 mitogen-activated protein kinase 8 Homo sapiens 192-195 17891170-3 2008 Edelfosine treatment recruited Hsp90, c-Jun N-terminal kinase (JNK) and apoptotic molecules in lipid rafts, but not the JNK regulators apoptosis signal-regulating kinase 1 (ASK1) and Daxx, or the survival signaling molecules extracellular signal-regulated kinase (ERK) and Akt. edelfosine 0-10 mitogen-activated protein kinase 8 Homo sapiens 38-61 17891170-3 2008 Edelfosine treatment recruited Hsp90, c-Jun N-terminal kinase (JNK) and apoptotic molecules in lipid rafts, but not the JNK regulators apoptosis signal-regulating kinase 1 (ASK1) and Daxx, or the survival signaling molecules extracellular signal-regulated kinase (ERK) and Akt. edelfosine 0-10 mitogen-activated protein kinase 8 Homo sapiens 63-66 12851688-6 2003 Three out of the four edelfosine-sensitive NSCLC cell lines (NCI-H157, NCI-H520, NCI-H522) exhibit G2/M arrest, significant apoptosis and some degree of JNK activation in response to drug treatment. edelfosine 22-32 mitogen-activated protein kinase 8 Homo sapiens 153-156 16540473-4 2006 c-Jun amino-terminal kinase (JNK) and caspase-3 were accordingly activated at earlier times in edelfosine-treated Jurkat cells as compared with drug-treated HeLa cells. edelfosine 95-105 mitogen-activated protein kinase 8 Homo sapiens 29-32 16540473-7 2006 Edelfosine induced translocation of Fas, Fas-associated death domain-containing protein, and JNK into membrane rafts in Jurkat cells, but not in HeLa cells. edelfosine 0-10 mitogen-activated protein kinase 8 Homo sapiens 93-96 17974980-5 2007 Edelfosine also induced persistent c-Jun NH(2)-terminal kinase (JNK) activation. edelfosine 0-10 mitogen-activated protein kinase 8 Homo sapiens 35-62 17974980-5 2007 Edelfosine also induced persistent c-Jun NH(2)-terminal kinase (JNK) activation. edelfosine 0-10 mitogen-activated protein kinase 8 Homo sapiens 64-67 17974980-6 2007 Gene transfer-mediated overexpression of apoptosis signal-regulating kinase 1, which plays a crucial role in ER stress, enhanced edelfosine-induced JNK activation and apoptosis. edelfosine 129-139 mitogen-activated protein kinase 8 Homo sapiens 148-151 17974980-7 2007 Inhibition of JNK, caspase-4, or caspase-8 activation diminished edelfosine-induced apoptosis. edelfosine 65-75 mitogen-activated protein kinase 8 Homo sapiens 14-17 12851688-3 2003 The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP). edelfosine 41-51 mitogen-activated protein kinase 8 Homo sapiens 182-207 12851688-3 2003 The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP). edelfosine 41-51 mitogen-activated protein kinase 8 Homo sapiens 209-212 12851688-3 2003 The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP). edelfosine 110-120 mitogen-activated protein kinase 8 Homo sapiens 182-207 12851688-9 2003 These results demonstrate that edelfosine-induced changes in JNK, ERK, p38, or PARP are not good predictors of cell susceptibility to edelfosine-induced cytotoxicity. edelfosine 31-41 mitogen-activated protein kinase 8 Homo sapiens 61-64 9547349-2 1998 We show that ET-18-OCH3-induced apoptosis is associated with activation of the c-Jun NH2-terminal kinase (JNK) signaling. edelfosine 13-23 mitogen-activated protein kinase 8 Homo sapiens 106-109 9547349-0 1998 Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. edelfosine 118-171 mitogen-activated protein kinase 8 Homo sapiens 15-40 9547349-2 1998 We show that ET-18-OCH3-induced apoptosis is associated with activation of the c-Jun NH2-terminal kinase (JNK) signaling. edelfosine 13-23 mitogen-activated protein kinase 8 Homo sapiens 79-104 9547349-4 1998 We found that ET-18-OCH3 induced a persistent activation of JNK in HL-60 cells that was detected before the onset of apoptosis, the latter being assessed by DNA fragmentation and by the appearance of phosphatidylserine on the external leaflet of the plasma membrane. edelfosine 14-24 mitogen-activated protein kinase 8 Homo sapiens 60-63 9547349-7 1998 ET-18-OCH3-dependent JNK activation was not detected in K562 cells, which did not undergo apoptosis on treatment with ET-18-OCH3. edelfosine 0-10 mitogen-activated protein kinase 8 Homo sapiens 21-24 9547349-8 1998 Phorbol myristate acetate inhibited both ET-18-OCH3-induced apoptosis and sustained JNK activation; thus, persistent JNK activation by ET-18-OCH3 is associated with the capacity of this ether phospholipid to induce apoptosis. edelfosine 41-51 mitogen-activated protein kinase 8 Homo sapiens 117-120 9547349-8 1998 Phorbol myristate acetate inhibited both ET-18-OCH3-induced apoptosis and sustained JNK activation; thus, persistent JNK activation by ET-18-OCH3 is associated with the capacity of this ether phospholipid to induce apoptosis. edelfosine 135-145 mitogen-activated protein kinase 8 Homo sapiens 84-87 9547349-8 1998 Phorbol myristate acetate inhibited both ET-18-OCH3-induced apoptosis and sustained JNK activation; thus, persistent JNK activation by ET-18-OCH3 is associated with the capacity of this ether phospholipid to induce apoptosis. edelfosine 135-145 mitogen-activated protein kinase 8 Homo sapiens 117-120 9547349-10 1998 These data indicate that JNK activation and c-Jun are involved in the induction of apoptosis by ET-18-OCH3. edelfosine 96-106 mitogen-activated protein kinase 8 Homo sapiens 25-28