PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24628241-7 2014 Both raft- and ER-mediated proapoptotic responses require a mitochondrial-related step to eventually promote cell death, and overexpression of Bcl-2 or Bcl-xL prevents edelfosine-induced apoptosis. edelfosine 168-178 BCL2 apoptosis regulator Homo sapiens 143-148 9295281-11 1997 ET-18-OCH3 also inhibited stimulation of Bcl-2 by TPA and enhanced the decrease in Bcl-2 observed in ara-C-treated cells. edelfosine 0-10 BCL2 apoptosis regulator Homo sapiens 41-46 12421819-7 2003 Furthermore, ET-18-OCH3, a specific phospholipase C (PLC) inhibitor, blocks nicotine-stimulated Bcl2 phosphorylation and promotes apoptosis, suggesting that PLC may be involved in nicotine activation of Bcl2 kinases. edelfosine 13-23 BCL2 apoptosis regulator Homo sapiens 96-100 12421819-7 2003 Furthermore, ET-18-OCH3, a specific phospholipase C (PLC) inhibitor, blocks nicotine-stimulated Bcl2 phosphorylation and promotes apoptosis, suggesting that PLC may be involved in nicotine activation of Bcl2 kinases. edelfosine 13-23 BCL2 apoptosis regulator Homo sapiens 203-207 10738248-7 2000 Overexpression of bcl-2 by gene transfer prevented DeltaPsi(m) collapse, ROS generation, caspase activation and apoptosis in ET-18-OCH(3)-treated leukemic T cells. edelfosine 125-137 BCL2 apoptosis regulator Homo sapiens 18-23 9295281-11 1997 ET-18-OCH3 also inhibited stimulation of Bcl-2 by TPA and enhanced the decrease in Bcl-2 observed in ara-C-treated cells. edelfosine 0-10 BCL2 apoptosis regulator Homo sapiens 83-88 34065546-5 2021 The overexpression of Bcl-2 or Bcl-xL blocks edelfosine-induced apoptosis. edelfosine 45-55 BCL2 apoptosis regulator Homo sapiens 22-27 9102220-0 1997 Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L). edelfosine 68-78 BCL2 apoptosis regulator Homo sapiens 162-167 9102220-0 1997 Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L). edelfosine 80-90 BCL2 apoptosis regulator Homo sapiens 162-167