PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34439330-12 2021 The alkylphospholipid analog prototype edelfosine is selectively taken up by tumor cells, accumulates in the ER of a number of human solid tumor cells-including pancreatic cancer cells-and promotes apoptosis through a persistent ER-stress-mediated mechanism both in vitro and in vivo. edelfosine 39-49 epiregulin Homo sapiens 109-111 34439330-12 2021 The alkylphospholipid analog prototype edelfosine is selectively taken up by tumor cells, accumulates in the ER of a number of human solid tumor cells-including pancreatic cancer cells-and promotes apoptosis through a persistent ER-stress-mediated mechanism both in vitro and in vivo. edelfosine 39-49 epiregulin Homo sapiens 229-231 34065546-2 2021 Cumulative evidence shows that edelfosine interacts with cholesterol-rich lipid rafts, endoplasmic reticulum (ER) and mitochondria. edelfosine 31-41 epiregulin Homo sapiens 110-112 34065546-4 2021 Edelfosine-induced apoptosis, mediated by lipid rafts and/or ER, requires the involvement of a mitochondrial-dependent step to eventually elicit cell death, leading to the loss of mitochondrial membrane potential, cytochrome c release and the triggering of cell death. edelfosine 0-10 epiregulin Homo sapiens 61-63