PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23492771-0 2013 Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity. Cadmium 0-7 dynamin 1 like Homo sapiens 16-20 31676320-0 2019 Increasing ERK phosphorylation by inhibition of p38 activity protects against cadmium-induced apoptotic cell death through ERK/Drp1/p38 signaling axis in spermatocyte-derived GC-2spd cells. Cadmium 78-85 dynamin 1 like Homo sapiens 127-131 31285421-0 2019 Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes. Cadmium 81-88 dynamin 1 like Homo sapiens 0-4 31285421-5 2019 We aimed to explore the role and mechanism of Drp1 interaction with RB in hepatocyte"s necroptosis caused by cadmium (Cd). Cadmium 109-116 dynamin 1 like Homo sapiens 46-50 31285421-5 2019 We aimed to explore the role and mechanism of Drp1 interaction with RB in hepatocyte"s necroptosis caused by cadmium (Cd). Cadmium 118-120 dynamin 1 like Homo sapiens 46-50 31285421-12 2019 In summary, we found a new molecular mechanism of regulated cell death that Drp1 interacted with RB and promoted them mitochondrial translocation to mediate necroptosis and hepatic injury in hepatocytes induced by Cd-exposure. Cadmium 214-216 dynamin 1 like Homo sapiens 76-80 23492771-7 2013 Moreover, in L02 cells, Drp1 silencing could effectively reverse Cd-induced mitochondrial fragmentation and mitochondrial dysfunction. Cadmium 65-67 dynamin 1 like Homo sapiens 24-28 23492771-9 2013 Overall, our study indicated that Cd induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis to promote hepatotoxicity. Cadmium 34-36 dynamin 1 like Homo sapiens 45-49 23492771-10 2013 Manipulation of Drp1 may be the potential avenue for developing novel strategies to protect against cadmium-induced hepatotoxicity. Cadmium 100-107 dynamin 1 like Homo sapiens 16-20