PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34510229-0 2021 Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-kappaB pathway in vitro and in vivo. Cadmium 0-7 NLR family pyrin domain containing 3 Homo sapiens 53-58 34510229-6 2021 Knock-down of NLRP3 rescued the RPTEC/TERT1 cells from Cd-induced inflammatory damage. Cadmium 55-57 NLR family pyrin domain containing 3 Homo sapiens 14-19 33592257-6 2021 Our results revealed that Cd caused cerebral histopathology lesions, inducing cerebral pyroptosis and the mass generation of inflammatory cytokines, as indicated by the increased NLRP3 inflammasome activation (NLRP3, Cas1 and ASC) and the upregulation of inflammation factors IL-2, IL-6, IL-7 and inhibition of IL-10. Cadmium 26-28 NLR family pyrin domain containing 3 Homo sapiens 179-184 34098069-0 2021 Acute cadmium exposure induces GSDME-mediated pyroptosis in triple-negative breast cancer cells through ROS generation and NLRP3 inflammasome pathway activation. Cadmium 6-13 NLR family pyrin domain containing 3 Homo sapiens 123-128 33592257-6 2021 Our results revealed that Cd caused cerebral histopathology lesions, inducing cerebral pyroptosis and the mass generation of inflammatory cytokines, as indicated by the increased NLRP3 inflammasome activation (NLRP3, Cas1 and ASC) and the upregulation of inflammation factors IL-2, IL-6, IL-7 and inhibition of IL-10. Cadmium 26-28 NLR family pyrin domain containing 3 Homo sapiens 210-215 33497945-7 2020 Taken together, Cd exposure induces duck renal tubular epithelial cell pyroptosis through ROS/NLRP3/Caspase-1 signaling pathway, and inhibiting Caspase-1 dependent pyroptosis attenuates Cd-induced apoptosis. Cadmium 16-18 NLR family pyrin domain containing 3 Homo sapiens 94-99 33592257-8 2021 Furthermore, Cd caused mitochondrial dysfunction and fragmentation by inhibiting the AMPK-PGC-1alpha-NRF1/2 signaling pathway and reduced the expression of mitochondrial-related regulatory factors OPA1, TFAM and mtDNA, resulting in the increase of NLRP3 inflammasome. Cadmium 13-15 NLR family pyrin domain containing 3 Homo sapiens 248-253 33433347-5 2021 Simultaneously, Mo or/and Cd upregulated ASC, NLRP3, NEK7, Caspase-1, GSDMA, GSDME, IL-18 and IL-1beta mRNA levels and Caspase-1 p20, NLRP3, ASC, GSDMD protein levels, increased the percentage of pyroptotic cells, LDH, NO, IL-18 and IL-1beta releases as well as relative conductivity. Cadmium 26-28 NLR family pyrin domain containing 3 Homo sapiens 46-51 33433347-5 2021 Simultaneously, Mo or/and Cd upregulated ASC, NLRP3, NEK7, Caspase-1, GSDMA, GSDME, IL-18 and IL-1beta mRNA levels and Caspase-1 p20, NLRP3, ASC, GSDMD protein levels, increased the percentage of pyroptotic cells, LDH, NO, IL-18 and IL-1beta releases as well as relative conductivity. Cadmium 26-28 NLR family pyrin domain containing 3 Homo sapiens 134-139 33433347-6 2021 Moreover, NLRP3 inhibitor MCC950 and ROS scavenger BHA could ameliorate the above changed factors induced by Mo and Cd co-exposure. Cadmium 116-118 NLR family pyrin domain containing 3 Homo sapiens 10-15 33497945-0 2020 Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells. Cadmium 65-72 NLR family pyrin domain containing 3 Homo sapiens 18-23 33497945-4 2020 Simultaneously, Cd also markedly upregulated NLRP3, Caspase-1, ASC, NEK7, IL-1beta and IL-18 mRNA levels and NLRP3, Caspase-1 p20, GSDMD and ASC protein levels. Cadmium 16-18 NLR family pyrin domain containing 3 Homo sapiens 45-50 33497945-4 2020 Simultaneously, Cd also markedly upregulated NLRP3, Caspase-1, ASC, NEK7, IL-1beta and IL-18 mRNA levels and NLRP3, Caspase-1 p20, GSDMD and ASC protein levels. Cadmium 16-18 NLR family pyrin domain containing 3 Homo sapiens 109-114 30782482-6 2019 Real-time RT-PCR revealed that CD significantly increased NLRP3 and IL1B mRNA expression in different SMC cultures within 6 h of exposure. Cadmium 31-33 NLR family pyrin domain containing 3 Homo sapiens 58-63 31878134-7 2019 Furthermore, NF-kappaB, NLRP3, and MAPKs signaling pathways were all activated by Cd intoxication. Cadmium 82-84 NLR family pyrin domain containing 3 Homo sapiens 24-29 31878134-8 2019 In conclusion, the inhibition of Nrf2, HO-1, and the activation of NF-kappaB, NLRP3, and MAPKs all contribute to Cd-induced liver injury. Cadmium 113-115 NLR family pyrin domain containing 3 Homo sapiens 78-83 30782482-8 2019 Additional exposure of IFN-gamma-primed AAA-SMC to CD for 6-24 h, further augmented expression of AIM2, NLRP3, and Caspase-1 protein levels. Cadmium 51-53 NLR family pyrin domain containing 3 Homo sapiens 104-109 31878134-0 2019 Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-kappaB, NLRP3, and MAPKs Signaling Pathway. Cadmium 0-7 NLR family pyrin domain containing 3 Homo sapiens 81-86 26809137-0 2016 Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells. Cadmium 0-7 NLR family pyrin domain containing 3 Homo sapiens 16-21 26809137-5 2016 In addition, exposure of HUVECs to Cd resulted in NLRP3 inflammasome activation as evidenced by cleavage of caspase-1 and downstream interleukin (IL)-1beta production. Cadmium 35-37 NLR family pyrin domain containing 3 Homo sapiens 50-55 26809137-6 2016 Moreover, knockdown of NLRP3 by small interfering RNA efficiently suppressed Cd-induced caspase-1 cleavage, IL-1beta production and pyroptosis in HUVECs. Cadmium 77-79 NLR family pyrin domain containing 3 Homo sapiens 23-28 26809137-8 2016 Accordingly, pre-treatment with mtROS scavenger or total ROS scavenger reduced Cd-induced activation of NLRP3 inflammasome and pyroptotic cell death. Cadmium 79-81 NLR family pyrin domain containing 3 Homo sapiens 104-109 26809137-9 2016 Taken together, our data suggest that NLRP3 inflammasome, activated by the generation of mtROS, mediates Cd-induced pyroptosis in HUVECs. Cadmium 105-107 NLR family pyrin domain containing 3 Homo sapiens 38-43