PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33679301-8 2021 We found that boldine interacts with Abeta in silico affecting its aggregation and protecting hippocampal neurons from synaptic failure induced by AbetaO. boldine 14-21 amyloid beta (A4) precursor protein Mus musculus 37-42 33679301-11 2021 We conclude that boldine provides neuroprotection in AD models by both direct interactions with Abeta and by preventing oxidative stress and mitochondrial dysfunction. boldine 17-24 amyloid beta (A4) precursor protein Mus musculus 96-101 33679301-12 2021 Additional studies are required to evaluate the effect of boldine on cognitive and behavioral deficits induced by Abeta in vivo. boldine 58-65 amyloid beta (A4) precursor protein Mus musculus 114-119