PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33535961-10 2021 In addition, the study was found that boldine significantly inhibited the cellular proliferative markers like PCNA and Ki67 and regulated the specific cell cycle associated proteins by up-regulated expression of p21Cip1/Kip1 and p27 Cip1/Kip1 and down-regulated expression of Cyclin D1, CDK 4, Cyclin E1, and CDK 2. boldine 38-45 cyclin E1 Rattus norvegicus 294-303