PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32809100-13	2021	Direct AGE inhibitors currently investigated include pyridoxamine and epalrestat, the inhibition of the formation of reactive dicarbonyls such as methylglyoxal as an important precursor of AGEs via increased activation of the detoxifying enzyme Glo-1 and inhibitors of NOX-derived ROS to reduce the AGE/RAGE signalling.	dicarbonyls	126-137	glyoxalase I	Homo sapiens	245-250	
24767709-3	2015	Dicarbonyls, in particular methylglyoxal, participate in the development of atherosclerosis, and their major detoxification route is the enzyme glyoxalase 1 (GLO1), which is known to decrease during aging.	dicarbonyls	0-11	glyoxalase I	Homo sapiens	144-156	
24767709-3	2015	Dicarbonyls, in particular methylglyoxal, participate in the development of atherosclerosis, and their major detoxification route is the enzyme glyoxalase 1 (GLO1), which is known to decrease during aging.	dicarbonyls	0-11	glyoxalase I	Homo sapiens	158-162	
23201419-1	2013	The glyoxalase system and its main enzyme, glyoxalase 1 (GLO1), protect cells from advanced glycation end products (AGEs), such as methylglyoxal (MG) and other reactive dicarbonyls, the formation of which is increased in diabetes patients as a result of excessive glycolysis.	dicarbonyls	169-180	glyoxalase I	Homo sapiens	43-55	
23201419-1	2013	The glyoxalase system and its main enzyme, glyoxalase 1 (GLO1), protect cells from advanced glycation end products (AGEs), such as methylglyoxal (MG) and other reactive dicarbonyls, the formation of which is increased in diabetes patients as a result of excessive glycolysis.	dicarbonyls	169-180	glyoxalase I	Homo sapiens	57-61	
22325990-6	2012	GSH also modulates the activity of glyoxalase 1 (Glo-1), the rate-limiting enzyme for the removal of reactive dicarbonyls such as methylglyoxal (MG).	dicarbonyls	110-121	glyoxalase I	Homo sapiens	35-47	
22325990-6	2012	GSH also modulates the activity of glyoxalase 1 (Glo-1), the rate-limiting enzyme for the removal of reactive dicarbonyls such as methylglyoxal (MG).	dicarbonyls	110-121	glyoxalase I	Homo sapiens	49-54	
22500508-5	2012	The glyoxalase system, composed of the enzymes glyoxalase I (GLO1) and glyoxalase II, is the main detoxification pathway involved in breaking down toxic reactive dicarbonyls before producing carbonyl stress and forming AGEs on proteins, lipids, or nucleic acids.	dicarbonyls	162-173	glyoxalase I	Homo sapiens	47-59	
22500508-5	2012	The glyoxalase system, composed of the enzymes glyoxalase I (GLO1) and glyoxalase II, is the main detoxification pathway involved in breaking down toxic reactive dicarbonyls before producing carbonyl stress and forming AGEs on proteins, lipids, or nucleic acids.	dicarbonyls	162-173	glyoxalase I	Homo sapiens	61-65