PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26586210-3 2016 We found that in primary human amniocytes, Atosiban (10 muM) signals via PTX-sensitive Galphai to activate transcription factor NF-kappaB p65, ERK1/2, and p38 which subsequently drives upregulation of the prostaglandin synthesis enzymes, COX-2 and phospho-cPLA2 and excretion of prostaglandins (PGE2) (n = 6; p < 0.05, ANOVA). galphai 87-94 mitogen-activated protein kinase 1 Homo sapiens 155-158 24385109-5 2014 These effects triggered by HDL were inhibited by pertussis toxin (PTX), protein kinase C (PKC) inhibitor GF109203X, and ERK inhibitor PD98059, suggesting that Galphai/Galphao-coupled GPCR, PKC, and ERK pathways are involved in HDL-induced COX-2/PGI-2 activation. galphai 159-166 mitogen-activated protein kinase 1 Homo sapiens 120-123 24385109-5 2014 These effects triggered by HDL were inhibited by pertussis toxin (PTX), protein kinase C (PKC) inhibitor GF109203X, and ERK inhibitor PD98059, suggesting that Galphai/Galphao-coupled GPCR, PKC, and ERK pathways are involved in HDL-induced COX-2/PGI-2 activation. galphai 159-166 mitogen-activated protein kinase 1 Homo sapiens 198-201