PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23108394-0 2013 The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Epirubicin 80-90 forkhead box M1 Homo sapiens 4-19 24362530-4 2014 We show that FOXM1 SUMOylation is enhanced in MCF-7 breast cancer cells in response to treatment with epirubicin and mitotic inhibitors. Epirubicin 102-112 forkhead box M1 Homo sapiens 13-18 24141789-0 2014 FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Epirubicin 65-75 forkhead box M1 Homo sapiens 0-5 24141789-5 2014 Like FOXM1, NBS1 is overexpressed in the epirubicin-resistant MCF-7Epi(R) cells and its expression level is low but inducible by epirubicin in MCF-7 cells. Epirubicin 41-51 forkhead box M1 Homo sapiens 5-10 24141789-6 2014 Consistently, overexpression of FOXM1 augmented and FOXM1 depletion reduced NBS1 expression and epirubicin-induced ataxia-telangiectasia mutated (ATM)phosphorylation in breast cancer cells. Epirubicin 96-106 forkhead box M1 Homo sapiens 32-37 24141789-6 2014 Consistently, overexpression of FOXM1 augmented and FOXM1 depletion reduced NBS1 expression and epirubicin-induced ataxia-telangiectasia mutated (ATM)phosphorylation in breast cancer cells. Epirubicin 96-106 forkhead box M1 Homo sapiens 52-57 27526106-0 2016 RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment. Epirubicin 93-103 forkhead box M1 Homo sapiens 39-44 27526106-5 2016 Co-immunoprecipitation studies in MCF-7 cells revealed that RNF168 interacted with FOXM1 and that upon epirubicin treatment FOXM1 downregulation was associated with an increase in RNF168 binding and conjugation to the protein degradation-associated K48-linked polyubiquitin chains. Epirubicin 103-113 forkhead box M1 Homo sapiens 124-129 27526106-7 2016 Conversely, RNF168, knockdown significantly enhanced the half-life of FOXM1 in both absence and presence of epirubicin. Epirubicin 108-118 forkhead box M1 Homo sapiens 70-75 27526106-11 2016 Moreover, we also obtained evidence that RNF8 recruits RNF168 to FOXM1 upon epirubicin treatment and cooperates with RNF168 to catalyse FOXM1 ubiquitination and degradation. Epirubicin 76-86 forkhead box M1 Homo sapiens 65-70 23108394-11 2013 These data suggest that FOXM1 regulates BRIP1 expression to modulate epirubicin-induced DNA damage repair and drug resistance. Epirubicin 69-79 forkhead box M1 Homo sapiens 24-29 23108394-3 2013 We find that FOXM1 expression is associated with epirubicin sensitivity and DSB repair. Epirubicin 49-59 forkhead box M1 Homo sapiens 13-18 23108394-4 2013 Ectopic expression of FOXM1 can increase cell viability and abrogate DSBs sustained by MCF-7 cells following epirubicin, owing to an enhancement in repair efficiency. Epirubicin 109-119 forkhead box M1 Homo sapiens 22-27 23108394-5 2013 Conversely, alkaline comet and gammaH2AX foci formation assays show that Foxm1-null cells are hypersensitive to DNA damage, epirubicin and gamma-irradiation. Epirubicin 124-134 forkhead box M1 Homo sapiens 73-78 23108394-8 2013 In agreement, depletion of FOXM1 expression by small interfering RNA downregulates BRIP1 expression at the protein and mRNA levels in MCF-7 and the epirubicin-resistant MCF-7 Epi(R) cells. Epirubicin 148-158 forkhead box M1 Homo sapiens 27-32 21518729-9 2011 In summary, our data show that ATM and p53 coordinately regulate FOXM1 via E2F to modulate epirubicin response and resistance in breast cancer. Epirubicin 91-101 forkhead box M1 Homo sapiens 65-70 22802261-0 2012 The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. Epirubicin 64-74 forkhead box M1 Homo sapiens 41-46 22802261-1 2012 E2F1 is responsible for the regulation of FOXM1 expression, which plays a key role in epirubicin resistance. Epirubicin 86-96 forkhead box M1 Homo sapiens 42-47 22802261-3 2012 We first showed that E2F1 plays a key role in promoting FOXM1 expression, cell survival, and epirubicin resistance as its depletion by siRNA attenuated FOXM1 induction and cell viability in response to epirubicin. Epirubicin 202-212 forkhead box M1 Homo sapiens 56-61 22802261-3 2012 We first showed that E2F1 plays a key role in promoting FOXM1 expression, cell survival, and epirubicin resistance as its depletion by siRNA attenuated FOXM1 induction and cell viability in response to epirubicin. Epirubicin 202-212 forkhead box M1 Homo sapiens 152-157 22802261-4 2012 We also found that the p38-MAPK activity mirrors the expression patterns of E2F1 and FOXM1 in both epirubicin-sensitive and -resistant MCF-7 breast cancer cells, suggesting that p38 has a role in regulating E2F1 expression and epirubicin resistance. Epirubicin 99-109 forkhead box M1 Homo sapiens 85-90 22802261-4 2012 We also found that the p38-MAPK activity mirrors the expression patterns of E2F1 and FOXM1 in both epirubicin-sensitive and -resistant MCF-7 breast cancer cells, suggesting that p38 has a role in regulating E2F1 expression and epirubicin resistance. Epirubicin 227-237 forkhead box M1 Homo sapiens 85-90 21518729-0 2011 ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. Epirubicin 63-73 forkhead box M1 Homo sapiens 21-26 21518729-1 2011 In this report, we investigated the role and regulation of forkhead box M1 (FOXM1) in breast cancer and epirubicin resistance. Epirubicin 104-114 forkhead box M1 Homo sapiens 59-74 21518729-2 2011 We generated epirubicin-resistant MCF-7 breast carcinoma (MCF-7-EPI(R)) cells and found FOXM1 protein levels to be higher in MCF-7-EPI(R) than in MCF-7 cells and that FOXM1 expression is downregulated by epirubicin in MCF-7 but not in MCF-7-EPI(R) cells. Epirubicin 13-23 forkhead box M1 Homo sapiens 88-93 21518729-2 2011 We generated epirubicin-resistant MCF-7 breast carcinoma (MCF-7-EPI(R)) cells and found FOXM1 protein levels to be higher in MCF-7-EPI(R) than in MCF-7 cells and that FOXM1 expression is downregulated by epirubicin in MCF-7 but not in MCF-7-EPI(R) cells. Epirubicin 13-23 forkhead box M1 Homo sapiens 167-172 21518729-2 2011 We generated epirubicin-resistant MCF-7 breast carcinoma (MCF-7-EPI(R)) cells and found FOXM1 protein levels to be higher in MCF-7-EPI(R) than in MCF-7 cells and that FOXM1 expression is downregulated by epirubicin in MCF-7 but not in MCF-7-EPI(R) cells. Epirubicin 204-214 forkhead box M1 Homo sapiens 88-93 21518729-3 2011 We also established that there is a loss of p53 function in MCF-7-EPI(R) cells and that epirubicin represses FOXM1 expression at transcription and gene promoter levels through activation of p53 and repression of E2F activity in MCF-7 cells. Epirubicin 88-98 forkhead box M1 Homo sapiens 109-114 21518729-5 2011 Moreover, transient promoter transfection assays showed that epirubicin and its cellular effectors p53 and E2F1 modulate FOXM1 transcription through an E2F-binding site located within the proximal promoter region. Epirubicin 61-71 forkhead box M1 Homo sapiens 121-126 21518729-6 2011 Chromatin immunoprecipitation analysis also revealed that epirubicin treatment increases pRB (retinoblastoma protein) and decreases E2F1 recruitment to the FOXM1 promoter region containing the E2F site. Epirubicin 58-68 forkhead box M1 Homo sapiens 156-161 21518729-7 2011 We also found ataxia-telangiectasia mutated (ATM) protein and mRNA to be overexpressed in the resistant MCF-7-EPI(R) cells compared with MCF-7 cells and that epirubicin could activate ATM to promote E2F activity and FOXM1 expression. Epirubicin 158-168 forkhead box M1 Homo sapiens 216-221