PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15273737-3	2004	TNFalpha pretreatment resulted in enhanced cleavage and activity of caspase-3 upon addition of etoposide, epirubicin or ceramide.	Epirubicin	106-116	caspase 3	Homo sapiens	68-77	
16331277-4	2006	Conversely, restoration of procaspase-3 sensitizes MCF-7 cells to chemotherapeutics including epirubicine, etoposide and taxol.	Epirubicin	94-105	caspase 3	Homo sapiens	27-39	
22163164-9	2011	Caspase-9 and caspase-3 activity was increased after applying antiresistant epirubicin mitosomes.	Epirubicin	76-86	caspase 3	Homo sapiens	14-23	
32565933-10	2020	The results indicated that LC3B protein expression was enhanced by EPI in a concentration-dependent manner, and the protein levels of cleaved caspase-3 and cleaved caspase-9 were higher in the combination group than in the EPI alone group.	Epirubicin	223-226	caspase 3	Homo sapiens	142-151	
11408917-9	2001	Epirubicin and pirarubicin, compounds closely related to ADR, also respectively enhanced 4.2-fold (p = 0.0052) and 2.8-fold (p = 0.0147) caspase-3 activity in ACHN cells.	Epirubicin	0-10	caspase 3	Homo sapiens	137-146	
30850026-10	2019	The percent of cells in SubG1 phase and activities of caspase-3/7 increased after DMAMCL treatment; The combination of DMAMCL with VCR or Epirubicin significantly increased cell death compared to each reagent alone.	Epirubicin	138-148	caspase 3	Homo sapiens	54-63	
32357825-12	2020	CONCLUSION: Epirubicin induced apoptosis in human bladder cancer cells by up-regulating the expression of pro-apoptotic factors (caspase-3, p53 and Bax) and down-regulating the expression of anti-apoptotic factor (Bcl-2).	Epirubicin	12-22	caspase 3	Homo sapiens	129-138	
25535473-4	2015	Results of the mechanism study highlighted the cooperation between SG and epirubicin or paclitaxel in activating caspase-3 and -9 but not caspase-8.	Epirubicin	74-84	caspase 3	Homo sapiens	113-129	
25268149-9	2016	The level of the tumor suppressor protein p53 in HeLa cells increased significantly upon treatment with free epirubicin, but remained relatively unchanged when cells were treated with equivalent dose of nanoparticle-loaded drug, suggesting a possible shift from p53-dependent DNA/RNA intercalation-based induction of cytotoxicity by free epirubicin to a caspase 3-induced cell death by the epirubicin-loaded PBCA formulation.	Epirubicin	109-119	caspase 3	Homo sapiens	354-363	
27609577-6	2016	After the cells were treated with 0.5 mg/L(IC50) epirubicin, the apoptosis rate of MGC-803 cells was raised, the protein expressions of caspase-3 , caspase-9 and Bax were significantly upregulated and Bcl-2 was downregulated.	Epirubicin	49-59	caspase 3	Homo sapiens	136-145	
28968471-10	2017	The combined treatments of siHuR and epirubicin significantly reduced the expression of Bcl-2, but increased the expression of Bax, as well as activity and expression levels of caspase-3 and -9.	Epirubicin	37-47	caspase 3	Homo sapiens	177-193	
26809377-2	2016	Epirubicin-induced decrease in cell viability and increase in caspase-3/7 activity were reversed by a cAMP analog dibutyryl cAMP (DBcAMP) or an activator of adenylate cyclase forskolin concomitant with a phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine.	Epirubicin	0-10	caspase 3	Homo sapiens	62-71	
22131069-8	2012	Epirubicin treatment up-regulated death receptor 4 (DR-4) and DR-5 expression and down-regulated FLIP expression, thereby enhancing the activation of procaspase 3, procaspase 8, and procaspase 9.	Epirubicin	0-10	caspase 3	Homo sapiens	150-162	
24594218-5	2014	RESULTS: HA22T/VGH cells treated with epirubicin increased the production of reactive oxygen species and nitric oxide, the expression of Fas, FasL, and Fas-associated death domain, and the activities of caspase-8 and caspase-3.	Epirubicin	38-48	caspase 3	Homo sapiens	217-226	
24971383-8	2014	Cotreatment with progesterone enhanced epirubicin-induced apoptosis, as evidenced by greater increase in caspase-3 activity and in the ratio of the apoptosis-regulating protein, Bax/Bcl-X(L).	Epirubicin	39-49	caspase 3	Homo sapiens	105-114	
22330067-6	2012	Epirubicin increased the activity of caspase-3/7, apoptotic cells, and intracellular lipid peroxide levels, and also induced depolarization of mitochondrial membranes.	Epirubicin	0-10	caspase 3	Homo sapiens	37-46	
22330067-8	2012	The epirubicin-induced cell injury and increase of caspase-3/7 activity were also attenuated by p38 mitogen-activated protein kinase (MAPK) inhibitors, SB203580 and PD169316.	Epirubicin	4-14	caspase 3	Homo sapiens	51-60	
21906442-5	2011	The expression levels of caspase-3, -8, -9, c-FLIP, Bcl-2, p53, and p21 in the FLS changed after epirubicin treatment.	Epirubicin	97-107	caspase 3	Homo sapiens	25-42	
21468584-4	2011	Moreover, even more notable cleavage of caspase-3 and 8 was detected with the combination of epirubicin and TRAIL.	Epirubicin	93-103	caspase 3	Homo sapiens	40-49