PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18606222-5	2008	GC and epirubicin significantly reduced mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulated the MDR1 promoter region; suppressed the mRNA expression of Bcl-2; induced the mRNA expression of Bax; and significantly increased the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3.	Epirubicin	7-17	BCL2 associated X, apoptosis regulator	Homo sapiens	242-245	
24971383-8	2014	Cotreatment with progesterone enhanced epirubicin-induced apoptosis, as evidenced by greater increase in caspase-3 activity and in the ratio of the apoptosis-regulating protein, Bax/Bcl-X(L).	Epirubicin	39-49	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181	
18606222-5	2008	GC and epirubicin significantly reduced mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulated the MDR1 promoter region; suppressed the mRNA expression of Bcl-2; induced the mRNA expression of Bax; and significantly increased the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3.	Epirubicin	7-17	BCL2 associated X, apoptosis regulator	Homo sapiens	279-282	
31433581-9	2019	RESULTS: Epirubicin inhibited proliferation in a dose-dependent manner, induced apoptosis, decreased the expression of Bcl-2, and increased the expressions of Bax, cleaved-caspase-3, and cleaved-PARP1 in osteosarcoma cells.	Epirubicin	9-19	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162	
16109560-1	2005	OBJECTIVE: To observe the expression of Bcl-2 and Bax proteins and cell apoptosis induced by preoperative lymphatic chemotherapy with epirubicin-activated carbon suspension (Epi-CH) in the cells of axillary metastatic lymph node of breast cancer and investigate the mechanism.	Epirubicin	134-144	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53	
8690514-5	1996	Induction of bax-alpha expression did not affect viability by itself but strongly increased chemosensitivity to epirubicin.	Epirubicin	112-122	BCL2 associated X, apoptosis regulator	Homo sapiens	13-16	
32357825-12	2020	CONCLUSION: Epirubicin induced apoptosis in human bladder cancer cells by up-regulating the expression of pro-apoptotic factors (caspase-3, p53 and Bax) and down-regulating the expression of anti-apoptotic factor (Bcl-2).	Epirubicin	12-22	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151	
30304783-5	2018	We found that the combined use of dihydroartemisinin with epirubicin could efficiently inhibit the activity of Bcl-2, facilitate release of Beclin 1, and further activate Bax.	Epirubicin	58-68	BCL2 associated X, apoptosis regulator	Homo sapiens	171-174	
28968471-10	2017	The combined treatments of siHuR and epirubicin significantly reduced the expression of Bcl-2, but increased the expression of Bax, as well as activity and expression levels of caspase-3 and -9.	Epirubicin	37-47	BCL2 associated X, apoptosis regulator	Homo sapiens	127-130	
25535473-5	2015	Moreover, SG significantly increased the mitochondrial accumulation of both Bax and Bak triggered by epirubicin or paclitaxel as well as the subsequent release of cytochrome c in the targeted cells.	Epirubicin	101-111	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79	
27609577-6	2016	After the cells were treated with 0.5 mg/L(IC50) epirubicin, the apoptosis rate of MGC-803 cells was raised, the protein expressions of caspase-3 , caspase-9 and Bax were significantly upregulated and Bcl-2 was downregulated.	Epirubicin	49-59	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165